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Characterization of Enzymes Involved in Nintedanib Metabolism in Humans.
Nakashima S, Sato R, Fukami T, Kudo T, Hashiba S, Morinaga G, Nakano M, Ludwig-Schwellinger E, Matsui A, Ishiguro N, Ebner T, Nakajima M. Nakashima S, et al. Among authors: matsui a. Drug Metab Dispos. 2023 Jun;51(6):733-742. doi: 10.1124/dmd.122.001113. Epub 2023 Mar 16. Drug Metab Dispos. 2023. PMID: 36927840
Iminium ion metabolites are formed from nintedanib by human CYP3A4.
Nakashima S, Fukami T, Kudo T, Nakano M, Matsui A, Ishiguro N, Nakajima M. Nakashima S, et al. Among authors: matsui a. Drug Metab Pharmacokinet. 2024 Aug;57:101025. doi: 10.1016/j.dmpk.2024.101025. Epub 2024 Jun 10. Drug Metab Pharmacokinet. 2024. PMID: 39068856
SFTG international collaborative study on in vitro micronucleus test IV. Using CHL cells.
Wakata A, Matsuoka A, Yamakage K, Yoshida J, Kubo K, Kobayashi K, Senjyu N, Itoh S, Miyajima H, Hamada S, Nishida S, Araki H, Yamamura E, Matsui A, Thybaud V, Lorenzon G, Marzin D, Lorge E. Wakata A, et al. Among authors: matsui a. Mutat Res. 2006 Aug 4;607(1):88-124. doi: 10.1016/j.mrgentox.2006.04.003. Epub 2006 Jun 19. Mutat Res. 2006. PMID: 16782396
834 results