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Page 1
An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy.
Cowles SC, Sheen A, Santollani L, Lutz EA, Lax BM, Palmeri JR, Freeman GJ, Wittrup KD. Cowles SC, et al. Among authors: santollani l. MAbs. 2022 Jan-Dec;14(1):2088454. doi: 10.1080/19420862.2022.2088454. MAbs. 2022. PMID: 35924382 Free PMC article.
Local delivery of cell surface-targeted immunocytokines programs systemic anti-tumor immunity.
Santollani L, Zhang YJ, Maiorino L, Palmeri JR, Stinson JA, Duhamel LR, Qureshi K, Suggs JR, Porth OT, Pinney W 3rd, Msari RA, Wittrup KD, Irvine DJ. Santollani L, et al. bioRxiv [Preprint]. 2024 Jan 3:2024.01.03.573641. doi: 10.1101/2024.01.03.573641. bioRxiv. 2024. Update in: Nat Immunol. 2024 Oct;25(10):1820-1829. doi: 10.1038/s41590-024-01925-7 PMID: 38260254 Free PMC article. Updated. Preprint.
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies.
Lax BM, Palmeri JR, Lutz EA, Sheen A, Stinson JA, Duhamel L, Santollani L, Kennedy A, Rothschilds AM, Spranger S, Sansom DM, Wittrup KD. Lax BM, et al. Among authors: santollani l. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2300895120. doi: 10.1073/pnas.2300895120. Epub 2023 Jul 24. Proc Natl Acad Sci U S A. 2023. PMID: 37487077 Free PMC article.
Tregs constrain CD8+ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy.
Palmeri JR, Lax BM, Peters JM, Duhamel L, Stinson JA, Santollani L, Lutz EA, Pinney W 3rd, Bryson BD, Wittrup KD. Palmeri JR, et al. Among authors: santollani l. bioRxiv [Preprint]. 2023 Feb 1:2023.01.30.526116. doi: 10.1101/2023.01.30.526116. bioRxiv. 2023. Update in: Nat Commun. 2024 Mar 1;15(1):1900. doi: 10.1038/s41467-024-45625-0 PMID: 36778460 Free PMC article. Updated. Preprint.