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The first-in-class ERK inhibitor ulixertinib shows promising activity in mitogen-activated protein kinase (MAPK)-driven pediatric low-grade glioma models.
Sigaud R, Rösch L, Gatzweiler C, Benzel J, von Soosten L, Peterziel H, Selt F, Najafi S, Ayhan S, Gerloff XF, Hofmann N, Büdenbender I, Schmitt L, Foerster KI, Burhenne J, Haefeli WE, Korshunov A, Sahm F, van Tilburg CM, Jones DTW, Pfister SM, Knoerzer D, Kreider BL, Sauter M, Pajtler KW, Zuckermann M, Oehme I, Witt O, Milde T. Sigaud R, et al. Among authors: von soosten l. Neuro Oncol. 2023 Mar 14;25(3):566-579. doi: 10.1093/neuonc/noac183. Neuro Oncol. 2023. PMID: 35882450 Free PMC article.
Making the invisible enemy visible.
Croll TI, Diederichs K, Fischer F, Fyfe CD, Gao Y, Horrell S, Joseph AP, Kandler L, Kippes O, Kirsten F, Müller K, Nolte K, Payne AM, Reeves M, Richardson JS, Santoni G, Stäb S, Tronrud DE, von Soosten LC, Williams CJ, Thorn A. Croll TI, et al. Among authors: von soosten lc. Nat Struct Mol Biol. 2021 May;28(5):404-408. doi: 10.1038/s41594-021-00593-7. Nat Struct Mol Biol. 2021. PMID: 33972785 Free PMC article.
Making the invisible enemy visible.
Croll T, Diederichs K, Fischer F, Fyfe C, Gao Y, Horrell S, Joseph AP, Kandler L, Kippes O, Kirsten F, Müller K, Nolte K, Payne A, Reeves MG, Richardson J, Santoni G, Stäb S, Tronrud D, von Soosten L, Williams C, Thorn A. Croll T, et al. Among authors: von soosten l. bioRxiv [Preprint]. 2020 Dec 28:2020.10.07.307546. doi: 10.1101/2020.10.07.307546. bioRxiv. 2020. Update in: Nat Struct Mol Biol. 2021 May;28(5):404-408. doi: 10.1038/s41594-021-00593-7 PMID: 33052340 Free PMC article. Updated. Preprint.