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Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer.
Chen Y, Yang S, Tavormina J, Tampe D, Zeisberg M, Wang H, Mahadevan KK, Wu CJ, Sugimoto H, Chang CC, Jenq RR, McAndrews KM, Kalluri R. Chen Y, et al. Among authors: wu cj. Cancer Cell. 2022 Aug 8;40(8):818-834.e9. doi: 10.1016/j.ccell.2022.06.011. Epub 2022 Jul 21. Cancer Cell. 2022. PMID: 35868307 Free PMC article.
Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer.
Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Kapoor A, et al. Among authors: wu cj. Cell. 2014 Jul 3;158(1):185-197. doi: 10.1016/j.cell.2014.06.003. Epub 2014 Jun 19. Cell. 2014. PMID: 24954535 Free PMC article.
Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis.
Lovisa S, Fletcher-Sananikone E, Sugimoto H, Hensel J, Lahiri S, Hertig A, Taduri G, Lawson E, Dewar R, Revuelta I, Kato N, Wu CJ, Bassett RL Jr, Putluri N, Zeisberg M, Zeisberg EM, LeBleu VS, Kalluri R. Lovisa S, et al. Among authors: wu cj. Sci Signal. 2020 Jun 9;13(635):eaaz2597. doi: 10.1126/scisignal.aaz2597. Sci Signal. 2020. PMID: 32518142 Free PMC article.
Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer.
Gulhati P, Schalck A, Jiang S, Shang X, Wu CJ, Hou P, Ruiz SH, Soto LS, Parra E, Ying H, Han J, Dey P, Li J, Deng P, Sei E, Maeda DY, Zebala JA, Spring DJ, Kim M, Wang H, Maitra A, Moore D, Clise-Dwyer K, Wang YA, Navin NE, DePinho RA. Gulhati P, et al. Among authors: wu cj. Nat Cancer. 2023 Jan;4(1):62-80. doi: 10.1038/s43018-022-00500-z. Epub 2022 Dec 30. Nat Cancer. 2023. PMID: 36585453 Free PMC article.
An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer.
Lu X, Pan X, Wu CJ, Zhao D, Feng S, Zang Y, Lee R, Khadka S, Amin SB, Jin EJ, Shang X, Deng P, Luo Y, Morgenlander WR, Weinrich J, Lu X, Jiang S, Chang Q, Navone NM, Troncoso P, DePinho RA, Wang YA. Lu X, et al. Among authors: wu cj. Cancer Res. 2018 Jul 15;78(14):3823-3833. doi: 10.1158/0008-5472.CAN-17-3564. Epub 2018 May 16. Cancer Res. 2018. PMID: 29769196 Free PMC article.
Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer.
Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Kapoor A, et al. Among authors: wu cj. Cell. 2019 Nov 14;179(5):1239. doi: 10.1016/j.cell.2019.10.037. Cell. 2019. PMID: 31730860 Free PMC article. No abstract available.
1,905 results