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Page 1
Evaluation of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase (DAHPS) as a Vulnerable Target in Mycobacterium tuberculosis.
Galina L, Hopf FSM, Abbadi BL, Sperotto NDM, Czeczot AM, Duque-Villegas MA, Perello MA, Matter LB, de Souza EV, Parish T, Machado P, Basso LA, Bizarro CV. Galina L, et al. Among authors: perello ma. Microbiol Spectr. 2022 Aug 31;10(4):e0072822. doi: 10.1128/spectrum.00728-22. Epub 2022 Jul 14. Microbiol Spectr. 2022. PMID: 35862980 Free PMC article.
Targeting thymidine phosphorylase inhibition in human colorectal cancer xenografts.
Sperotto NDM, Silva RBM, Perelló MA, Borsoi AF, da Silva Dadda A, Roth CD, Freitas RDS, de Souza APD, Freitas DDN, Picada JN, de Sousa JT, Nabinger DD, Altenhofen S, Bonan CD, Rodrigues-Junior VS, Bizarro CV, Basso LA, Machado P. Sperotto NDM, et al. Among authors: perello ma. Biomed Pharmacother. 2021 Jul;139:111672. doi: 10.1016/j.biopha.2021.111672. Epub 2021 May 6. Biomed Pharmacother. 2021. PMID: 33965731 Free article.
EPSP Synthase-Depleted Cells Are Aromatic Amino Acid Auxotrophs in Mycobacterium smegmatis.
Duque-Villegas MA, Abbadi BL, Romero PR, Matter LB, Galina L, Dalberto PF, Rodrigues-Junior VDS, Ducati RG, Roth CD, Rambo RS, de Souza EV, Perello MA, Morbidoni HR, Machado P, Basso LA, Bizarro CV. Duque-Villegas MA, et al. Among authors: perello ma. Microbiol Spectr. 2021 Dec 22;9(3):e0000921. doi: 10.1128/Spectrum.00009-21. Epub 2021 Dec 22. Microbiol Spectr. 2021. PMID: 34937164 Free PMC article.
Antitubercular Activity of Novel 2-(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties.
Borsoi AF, Alice LM, Sperotto N, Ramos AS, Abbadi BL, Macchi Hopf FS, Silva Dadda AD, Rambo RS, Madeira Silva RB, Paz JD, Pissinate K, Muniz MN, Neves CE, Galina L, González LC, Perelló MA, de Matos Czeczot A, Leyser M, de Oliveira SD, de Araújo Lock G, de Araújo BV, Costa TD, Bizarro CV, Basso LA, Machado P. Borsoi AF, et al. Among authors: perello ma. ACS Med Chem Lett. 2022 Jul 21;13(8):1337-1344. doi: 10.1021/acsmedchemlett.2c00254. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978694 Free PMC article.
Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation.
Paz JD, Denise de Moura Sperotto N, Ramos AS, Pissinate K, da Silva Rodrigues Junior V, Abbadi BL, Borsoi AF, Rambo RS, Corso Minotto AC, da Silva Dadda A, Galina L, Macchi Hopf FS, Muniz MN, Borges Martinelli LK, Roth CD, Madeira Silva RB, Perelló MA, de Matos Czeczot A, Neves CE, Duarte LS, Leyser M, Dias de Oliveira S, Bizarro CV, Machado P, Basso LA. Paz JD, et al. Among authors: perello ma. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114908. doi: 10.1016/j.ejmech.2022.114908. Epub 2022 Nov 18. Eur J Med Chem. 2023. PMID: 36435016
Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments.
Freitas de Freitas T, Roth CD, Abbadi BL, Hopf FSM, Perelló MA, de Matos Czeczot A, de Souza EV, Borsoi AF, Machado P, Bizarro CV, Basso LA, Timmers LFSM. Freitas de Freitas T, et al. Among authors: perello ma. J Comput Aided Mol Des. 2023 Mar;37(3):117-128. doi: 10.1007/s10822-022-00495-w. Epub 2022 Dec 22. J Comput Aided Mol Des. 2023. PMID: 36547753 Free PMC article.
Identification of antimycobacterial 8-hydroxyquinoline derivatives as in vitro enzymatic inhibitors of Mycobacterium tuberculosis enoyl-acyl carrier protein reductase.
Joaquim AR, Lopes MS, Fortes IS, de Bem Gentz C, de Matos Czeczot A, Perelló MA, Roth CD, Vainstein MH, Basso LA, Bizarro CV, Machado P, de Andrade SF. Joaquim AR, et al. Among authors: perello ma. Bioorg Chem. 2024 Oct;151:107705. doi: 10.1016/j.bioorg.2024.107705. Epub 2024 Aug 10. Bioorg Chem. 2024. PMID: 39137600
Crystal structure of dihydroneopterin aldolase from Mycobacterium tuberculosis associated with 8-mercaptoguanine, and development of novel S8-functionalized analogues as inhibitors: Synthesis, enzyme inhibition, in vitro toxicity and antitubercular activity.
Czeczot AM, Muniz MN, Perelló MA, Silva ÉED, Timmers LFSM, Berger A, Gonzalez LC, Arraché Gonçalves G, Moura S, Machado P, Bizarro CV, Basso LA. Czeczot AM, et al. Among authors: perello ma. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2388207. doi: 10.1080/14756366.2024.2388207. Epub 2024 Aug 14. J Enzyme Inhib Med Chem. 2024. PMID: 39140692 Free PMC article.
Unveiling the Antimycobacterial Potential of Novel 4-Alkoxyquinolines: Insights into Selectivity, Mechanism of Action, and In Vivo Exposure.
da Silva FF, Paz JD, Rambo RS, Gonçalves GA, Muniz MN, de Matos Czeczot A, Perelló MA, Berger A, González LC, Duarte LS, da Silva AB, Ferreira CAS, de Oliveira SD, Moura S, Bizarro CV, Basso LA, Machado P. da Silva FF, et al. Among authors: perello ma. J Med Chem. 2024 Dec 26;67(24):21781-21794. doi: 10.1021/acs.jmedchem.4c01302. Epub 2024 Dec 4. J Med Chem. 2024. PMID: 39630172 Free PMC article.
13 results