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Page 1
Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21.
Mumford P, Tosh J, Anderle S, Gkanatsiou Wikberg E, Lau G, Noy S, Cleverley K, Saito T, Saido TC, Yu E, Brinkmalm G, Portelius E, Blennow K, Zetterberg H, Tybulewicz V, Fisher EMC, Wiseman FK. Mumford P, et al. Among authors: tosh j. J Neurosci. 2022 Aug 17;42(33):6453-6468. doi: 10.1523/JNEUROSCI.0521-22.2022. Epub 2022 Jul 14. J Neurosci. 2022. PMID: 35835549 Free PMC article.
Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.
Wiseman FK, Pulford LJ, Barkus C, Liao F, Portelius E, Webb R, Chávez-Gutiérrez L, Cleverley K, Noy S, Sheppard O, Collins T, Powell C, Sarell CJ, Rickman M, Choong X, Tosh JL, Siganporia C, Whittaker HT, Stewart F, Szaruga M; London Down syndrome consortium; Murphy MP, Blennow K, de Strooper B, Zetterberg H, Bannerman D, Holtzman DM, Tybulewicz VLJ, Fisher EMC; LonDownS Consortium. Wiseman FK, et al. Among authors: tosh jl. Brain. 2018 Aug 1;141(8):2457-2474. doi: 10.1093/brain/awy159. Brain. 2018. PMID: 29945247 Free PMC article.
Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus.
Granno S, Nixon-Abell J, Berwick DC, Tosh J, Heaton G, Almudimeegh S, Nagda Z, Rain JC, Zanda M, Plagnol V, Tybulewicz VLJ, Cleverley K, Wiseman FK, Fisher EMC, Harvey K. Granno S, et al. Among authors: tosh j. Sci Rep. 2019 May 13;9(1):7322. doi: 10.1038/s41598-019-43820-4. Sci Rep. 2019. PMID: 31086297 Free PMC article.
Gene expression dysregulation domains are not a specific feature of Down syndrome.
Ahlfors H, Anyanwu N, Pakanavicius E, Dinischiotu N, Lana-Elola E, Watson-Scales S, Tosh J, Wiseman F, Briscoe J, Page K, Fisher EMC, Tybulewicz VLJ. Ahlfors H, et al. Among authors: tosh j. Nat Commun. 2019 Jun 6;10(1):2489. doi: 10.1038/s41467-019-10129-9. Nat Commun. 2019. PMID: 31171815 Free PMC article.
Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes.
Lana-Elola E, Cater H, Watson-Scales S, Greenaway S, Müller-Winkler J, Gibbins D, Nemes M, Slender A, Hough T, Keskivali-Bond P, Scudamore CL, Herbert E, Banks GT, Mobbs H, Canonica T, Tosh J, Noy S, Llorian M, Nolan PM, Griffin JL, Good M, Simon M, Mallon AM, Wells S, Fisher EMC, Tybulewicz VLJ. Lana-Elola E, et al. Among authors: tosh j. Dis Model Mech. 2021 Oct 1;14(10):dmm049157. doi: 10.1242/dmm.049157. Epub 2021 Oct 15. Dis Model Mech. 2021. PMID: 34477842 Free PMC article.
Dissecting Alzheimer disease in Down syndrome using mouse models.
Choong XY, Tosh JL, Pulford LJ, Fisher EM. Choong XY, et al. Among authors: tosh jl. Front Behav Neurosci. 2015 Oct 13;9:268. doi: 10.3389/fnbeh.2015.00268. eCollection 2015. Front Behav Neurosci. 2015. PMID: 26528151 Free PMC article. Review.
67 results