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Page 1
Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine.
Spanjaard A, Shah R, de Groot D, Buoninfante OA, Morris B, Lieftink C, Pritchard C, Zürcher LM, Ormel S, Catsman JJI, de Korte-Grimmerink R, Siteur B, Proost N, Boadum T, van de Ven M, Song JY, Kreft M, van den Berk PCM, Beijersbergen RL, Jacobs H. Spanjaard A, et al. Nucleic Acids Res. 2022 Jul 22;50(13):7420-7435. doi: 10.1093/nar/gkac545. Nucleic Acids Res. 2022. PMID: 35819193 Free PMC article.
Strategy for Development of Site-Specific Ubiquitin Antibodies.
van Kruijsbergen I, Mulder MPC, Uckelmann M, van Welsem T, de Widt J, Spanjaard A, Jacobs H, El Oualid F, Ovaa H, van Leeuwen F. van Kruijsbergen I, et al. Among authors: spanjaard a. Front Chem. 2020 Feb 21;8:111. doi: 10.3389/fchem.2020.00111. eCollection 2020. Front Chem. 2020. PMID: 32154221 Free PMC article.
Molecular dependencies and genomic consequences of a global DNA damage tolerance defect.
de Groot D, Spanjaard A, Shah R, Kreft M, Morris B, Lieftink C, Catsman JJI, Ormel S, Ayidah M, Pilzecker B, Buoninfante OA, van den Berk PCM, Beijersbergen RL, Jacobs H. de Groot D, et al. Among authors: spanjaard a. Genome Biol. 2024 Dec 31;25(1):323. doi: 10.1186/s13059-024-03451-z. Genome Biol. 2024. PMID: 39741332 Free PMC article.
Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair.
Shah R, Aslam MA, Spanjaard A, de Groot D, Zürcher LM, Altelaar M, Hoekman L, Pritchard CEJ, Pilzecker B, van den Berk PCM, Jacobs H. Shah R, et al. Among authors: spanjaard a. PNAS Nexus. 2024 Jun 18;3(7):pgae242. doi: 10.1093/pnasnexus/pgae242. eCollection 2024 Jul. PNAS Nexus. 2024. PMID: 38957451 Free PMC article.
Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation.
Spanjaard A, Stratigopoulou M, de Groot D, Aslam M, van den Berk PCM, Stappenbelt C, Ayidah M, Catsman JJI, Pardieck IN, Kreft M, Arens R, Guikema JEJ, Jacobs H. Spanjaard A, et al. Front Immunol. 2023 Jan 9;13:986863. doi: 10.3389/fimmu.2022.986863. eCollection 2022. Front Immunol. 2023. PMID: 36700204 Free PMC article.
Mammalian life depends on two distinct pathways of DNA damage tolerance.
Buoninfante OA, Pilzecker B, Spanjaard A, de Groot D, Prekovic S, Song JY, Lieftink C, Ayidah M, Pritchard CEJ, Vivié J, Mcgrath KE, Huijbers IJ, Philipsen S, von Lindern M, Zwart W, Beijersbergen RL, Palis J, van den Berk PCM, Jacobs H. Buoninfante OA, et al. Among authors: spanjaard a. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2216055120. doi: 10.1073/pnas.2216055120. Epub 2023 Jan 20. Proc Natl Acad Sci U S A. 2023. PMID: 36669105 Free PMC article.
Two outbreaks of botulism associated with consumption of green olive paste, France, September 2011.
Pingeon JM, Vanbockstael C, Popoff MR, King LA, Deschamps B, Pradel G, Dupont H, Spanjaard A, Houdard A, Mazuet C, Belaizi B, Bourgeois S, Lemgueres S, Debbat K, Courant P, Quirin R, Malfait P. Pingeon JM, et al. Among authors: spanjaard a. Euro Surveill. 2011 Dec 8;16(49):20035. doi: 10.2807/ese.16.49.20035-en. Euro Surveill. 2011. PMID: 22172329 Free article.