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SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway.
Willett BJ, Grove J, MacLean OA, Wilkie C, De Lorenzo G, Furnon W, Cantoni D, Scott S, Logan N, Ashraf S, Manali M, Szemiel A, Cowton V, Vink E, Harvey WT, Davis C, Asamaphan P, Smollett K, Tong L, Orton R, Hughes J, Holland P, Silva V, Pascall DJ, Puxty K, da Silva Filipe A, Yebra G, Shaaban S, Holden MTG, Pinto RM, Gunson R, Templeton K, Murcia PR, Patel AH, Klenerman P, Dunachie S; PITCH Consortium; COVID-19 Genomics UK (COG-UK) Consortium; Haughney J, Robertson DL, Palmarini M, Ray S, Thomson EC. Willett BJ, et al. Among authors: orton r. Nat Microbiol. 2022 Aug;7(8):1161-1179. doi: 10.1038/s41564-022-01143-7. Epub 2022 Jul 7. Nat Microbiol. 2022. PMID: 35798890 Free PMC article.
The P681H Mutation in the Spike Glycoprotein of the Alpha Variant of SARS-CoV-2 Escapes IFITM Restriction and Is Necessary for Type I Interferon Resistance.
Lista MJ, Winstone H, Wilson HD, Dyer A, Pickering S, Galao RP, De Lorenzo G, Cowton VM, Furnon W, Suarez N, Orton R, Palmarini M, Patel AH, Snell L, Nebbia G, Swanson C, Neil SJD. Lista MJ, et al. Among authors: orton r. J Virol. 2022 Dec 14;96(23):e0125022. doi: 10.1128/jvi.01250-22. Epub 2022 Nov 9. J Virol. 2022. PMID: 36350154 Free PMC article.
Adeno-associated virus 2 infection in children with non-A-E hepatitis.
Ho A, Orton R, Tayler R, Asamaphan P, Herder V, Davis C, Tong L, Smollett K, Manali M, Allan J, Rawlik K, McDonald SE, Vink E, Pollock L, Gannon L, Evans C, McMenamin J, Roy K, Marsh K, Divala T, Holden MTG, Lockhart M, Yirrell D, Currie S, O'Leary M, Henderson D, Shepherd SJ, Jackson C, Gunson R, MacLean A, McInnes N, Bradley-Stewart A, Battle R, Hollenbach JA, Henderson P, Odam M, Chikowore P, Oosthuyzen W, Chand M, Hamilton MS, Estrada-Rivadeneyra D, Levin M, Avramidis N, Pairo-Castineira E, Vitart V, Wilkie C; DIAMONDS Consortium; ISARIC4C Investigators; Palmarini M, Ray S, Robertson DL, da Silva Filipe A, Willett BJ, Breuer J, Semple MG, Turner D, Baillie JK, Thomson EC. Ho A, et al. Among authors: orton r. Nature. 2023 May;617(7961):555-563. doi: 10.1038/s41586-023-05948-2. Epub 2023 Mar 30. Nature. 2023. PMID: 36996873 Free article.
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles.
Kamel W, Ruscica V, Embarc-Buh A, de Laurent ZR, Garcia-Moreno M, Demyanenko Y, Orton RJ, Noerenberg M, Madhusudhan M, Iselin L, Järvelin AI, Hannan M, Kitano E, Moore S, Merits A, Davis I, Mohammed S, Castello A. Kamel W, et al. Among authors: orton rj. Mol Cell. 2024 Dec 19;84(24):4896-4911.e7. doi: 10.1016/j.molcel.2024.11.015. Epub 2024 Dec 11. Mol Cell. 2024. PMID: 39642884 Free article.
Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome.
Ranum JN, Ledwith MP, Alnaji FG, Diefenbacher M, Orton R, Sloan E, Güereca M, Feltman EM, Smollett K, da Silva Filipe A, Conley M, Russell AB, Brooke CB, Hutchinson E, Mehle A. Ranum JN, et al. Among authors: orton r. Nucleic Acids Res. 2024 Apr 12;52(6):3199-3212. doi: 10.1093/nar/gkae133. Nucleic Acids Res. 2024. PMID: 38407436 Free PMC article.
Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome.
Ranum JN, Ledwith MP, Alnaji FG, Diefenbacher M, Orton R, Sloan E, Guereca M, Feltman EM, Smollett K, da Silva Filipe A, Conley M, Russell AB, Brooke CB, Hutchinson E, Mehle A. Ranum JN, et al. Among authors: orton r. bioRxiv [Preprint]. 2024 Feb 7:2023.12.12.570638. doi: 10.1101/2023.12.12.570638. bioRxiv. 2024. Update in: Nucleic Acids Res. 2024 Apr 12;52(6):3199-3212. doi: 10.1093/nar/gkae133 PMID: 38168266 Free PMC article. Updated. Preprint.
Omicron BA.2.86 cross-neutralising activity in community sera from the UK.
Willett BJ, Logan N, Scott S, Davis C, McSorley T, Asamaphan P, Hosie MJ, Olmo P, Grove J, Orton R, Ho A, Haughney J, Robertson DL, Thomson EC. Willett BJ, et al. Among authors: orton r. Lancet. 2023 Dec 2;402(10417):2075-2076. doi: 10.1016/S0140-6736(23)02397-8. Epub 2023 Nov 9. Lancet. 2023. PMID: 37952549 No abstract available.
156 results