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Phase I dose-escalation study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of an inhaled recombinant human ACE2.
Bauer M, Jorda A, Al-Jalali V, Wölfl-Duchek M, Bergmann F, Nussbaumer-Pröll A, Steindl A, Gugenberger R, Bischof S, Wimmer D, Idzko M, Zeitlinger M. Bauer M, et al. Among authors: gugenberger r. ERJ Open Res. 2024 Feb 19;10(1):00567-2023. doi: 10.1183/23120541.00567-2023. eCollection 2024 Jan. ERJ Open Res. 2024. PMID: 38375429 Free PMC article.
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants.
Monteil V, Eaton B, Postnikova E, Murphy M, Braunsfeld B, Crozier I, Kricek F, Niederhöfer J, Schwarzböck A, Breid H, Devignot S, Klingström J, Thålin C, Kellner MJ, Christ W, Havervall S, Mereiter S, Knapp S, Sanchez Jimenez A, Bugajska-Schretter A, Dohnal A, Ruf C, Gugenberger R, Hagelkruys A, Montserrat N, Kozieradzki I, Hasan Ali O, Stadlmann J, Holbrook MR, Schmaljohn C, Oostenbrink C, Shoemaker RH, Mirazimi A, Wirnsberger G, Penninger JM. Monteil V, et al. Among authors: gugenberger r. EMBO Mol Med. 2022 Aug 8;14(8):e15230. doi: 10.15252/emmm.202115230. Epub 2022 Jul 4. EMBO Mol Med. 2022. PMID: 35781796 Free PMC article.
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants.
Wirnsberger G, Monteil V, Eaton B, Postnikova E, Murphy M, Braunsfeld B, Crozier I, Kricek F, Niederhöfer J, Schwarzböck A, Breid H, Jimenez AS, Bugajska-Schretter A, Dohnal A, Ruf C, Gugenberger R, Hagelkruys A, Montserrat N, Holbrook MR, Oostenbrink C, Shoemaker RH, Mirazimi A, Penninger JM. Wirnsberger G, et al. Among authors: gugenberger r. bioRxiv [Preprint]. 2021 Sep 10:2021.09.10.459744. doi: 10.1101/2021.09.10.459744. bioRxiv. 2021. Update in: EMBO Mol Med. 2022 Aug 8;14(8):e15230. doi: 10.15252/emmm.202115230 PMID: 34545368 Free PMC article. Updated. Preprint.