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A limb-girdle muscular dystrophy 2I model of muscular dystrophy identifies corrective drug compounds for dystroglycanopathies.
Serafini PR, Feyder MJ, Hightower RM, Garcia-Perez D, Vieira NM, Lek A, Gibbs DE, Moukha-Chafiq O, Augelli-Szafran CE, Kawahara G, Widrick JJ, Kunkel LM, Alexander MS. Serafini PR, et al. Among authors: widrick jj. JCI Insight. 2018 Sep 20;3(18):e120493. doi: 10.1172/jci.insight.120493. eCollection 2018 Sep 20. JCI Insight. 2018. PMID: 30232282 Free PMC article.
IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism.
Regué L, Ji F, Flicker D, Kramer D, Pierce W, Davidoff T, Widrick JJ, Houstis N, Minichiello L, Dai N, Avruch J. Regué L, et al. Among authors: widrick jj. Mol Cell Biol. 2019 Mar 19;39(7):e00528-18. doi: 10.1128/MCB.00528-18. Print 2019 Apr 1. Mol Cell Biol. 2019. PMID: 30692269 Free PMC article.
Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species.
Tabebordbar M, Lagerborg KA, Stanton A, King EM, Ye S, Tellez L, Krunnfusz A, Tavakoli S, Widrick JJ, Messemer KA, Troiano EC, Moghadaszadeh B, Peacker BL, Leacock KA, Horwitz N, Beggs AH, Wagers AJ, Sabeti PC. Tabebordbar M, et al. Among authors: widrick jj. Cell. 2021 Sep 16;184(19):4919-4938.e22. doi: 10.1016/j.cell.2021.08.028. Epub 2021 Sep 9. Cell. 2021. PMID: 34506722 Free PMC article.
Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease.
Pearsall RS, Davies MV, Cannell M, Li J, Widrick J, Mulivor AW, Wallner S, Troy ME, Spaits M, Liharska K, Sako D, Castonguay R, Keates S, Grinberg AV, Suragani RNVS, Kumar R. Pearsall RS, et al. Sci Rep. 2019 Aug 6;9(1):11392. doi: 10.1038/s41598-019-47818-w. Sci Rep. 2019. PMID: 31388039 Free PMC article.
88 results