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An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry.
Lin X, Guo L, Lin S, Chen Z, Yang F, Yang J, Wang L, Wen A, Duan Y, Zhang X, Dai Y, Yin K, Yuan X, Yu C, He B, Cao Y, Dong H, Li J, Zhao Q, Lu G. Lin X, et al. Among authors: he b. Emerg Microbes Infect. 2022 Dec;11(1):1920-1935. doi: 10.1080/22221751.2022.2095308. Emerg Microbes Infect. 2022. PMID: 35757908 Free PMC article.
Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor.
Yue D, Chen Z, Yang F, Ye F, Lin S, He B, Cheng Y, Wang J, Chen Z, Lin X, Yang J, Chen H, Zhang Z, You Y, Sun H, Wen A, Wang L, Zheng Y, Cao Y, Li Y, Lu G. Yue D, et al. Among authors: he b. Sci Adv. 2020 May 13;6(20):eaba5147. doi: 10.1126/sciadv.aba5147. eCollection 2020 May. Sci Adv. 2020. PMID: 32426511 Free PMC article.
Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding.
Lin S, Chen Z, Zhang X, Wen A, Yuan X, Yu C, Yang J, He B, Cao Y, Lu G. Lin S, et al. Among authors: he b. Signal Transduct Target Ther. 2022 Feb 21;7(1):56. doi: 10.1038/s41392-022-00914-2. Signal Transduct Target Ther. 2022. PMID: 35190526 Free PMC article. No abstract available.
Structural basis of poxvirus A16/G9 binding for sub-complex formation.
Yang F, Lin S, Chen Z, Yue D, Yang M, He B, Cao Y, Dong H, Li J, Zhao Q, Lu G. Yang F, et al. Among authors: he b. Emerg Microbes Infect. 2023 Dec;12(1):2179351. doi: 10.1080/22221751.2023.2179351. Emerg Microbes Infect. 2023. PMID: 36757688 Free PMC article. No abstract available.
Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Chen H, Lin S, Yang F, Chen Z, Guo L, Yang J, Lin X, Wang L, Duan Y, Wen A, Zhang X, Dai Y, Yin K, Yuan X, Yu C, He Y, He B, Cao Y, Dong H, Li J, Zhao Q, Liu Q, Lu G. Chen H, et al. Among authors: he y, he b. PLoS Pathog. 2023 Oct 13;19(10):e1011694. doi: 10.1371/journal.ppat.1011694. eCollection 2023 Oct. PLoS Pathog. 2023. PMID: 37831643 Free PMC article.
7,995 results