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Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached.
Wilcock DJ, Badrock AP, Wong CW, Owen R, Guerin M, Southam AD, Johnston H, Telfer BA, Fullwood P, Watson J, Ferguson H, Ferguson J, Lloyd GR, Jankevics A, Dunn WB, Wellbrock C, Lorigan P, Ceol C, Francavilla C, Smith MP, Hurlstone AFL. Wilcock DJ, et al. Among authors: hurlstone afl. Cell Rep. 2022 Jun 21;39(12):110995. doi: 10.1016/j.celrep.2022.110995. Cell Rep. 2022. PMID: 35732120 Free PMC article.
BRAF as therapeutic target in melanoma.
Wellbrock C, Hurlstone A. Wellbrock C, et al. Biochem Pharmacol. 2010 Sep 1;80(5):561-7. doi: 10.1016/j.bcp.2010.03.019. Epub 2010 Mar 27. Biochem Pharmacol. 2010. PMID: 20350535 Review.
Fishing for melanoma drivers.
Hurlstone A. Hurlstone A. Pigment Cell Melanoma Res. 2014 Mar;27(2):155-6. doi: 10.1111/pcmr.12214. Epub 2014 Jan 29. Pigment Cell Melanoma Res. 2014. PMID: 24406049 No abstract available.
Heterogeneous tumor subpopulations cooperate to drive invasion.
Chapman A, Fernandez del Ama L, Ferguson J, Kamarashev J, Wellbrock C, Hurlstone A. Chapman A, et al. Cell Rep. 2014 Aug 7;8(3):688-95. doi: 10.1016/j.celrep.2014.06.045. Epub 2014 Jul 24. Cell Rep. 2014. PMID: 25066122 Free PMC article.
TP53 in the UV spotlight: a bona fide driver of melanoma.
Hurlstone A, Wellbrock C. Hurlstone A, et al. Pigment Cell Melanoma Res. 2014 Nov;27(6):1010-1. doi: 10.1111/pcmr.12302. Epub 2014 Sep 2. Pigment Cell Melanoma Res. 2014. PMID: 25102761 No abstract available.
An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.
Young HL, Rowling EJ, Bugatti M, Giurisato E, Luheshi N, Arozarena I, Acosta JC, Kamarashev J, Frederick DT, Cooper ZA, Reuben A, Gil J, Flaherty KT, Wargo JA, Vermi W, Smith MP, Wellbrock C, Hurlstone A. Young HL, et al. J Exp Med. 2017 Jun 5;214(6):1691-1710. doi: 10.1084/jem.20160855. Epub 2017 Apr 27. J Exp Med. 2017. PMID: 28450382 Free PMC article.
61 results