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Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl.
Sun H, Cardinal KA, Wienkers L, Chin A, Kumar V, Neace C, Henderson C, Endres CJ, Topletz-Erickson A, Regal K, Vo A, Alley SC, Lee AJ. Sun H, et al. Among authors: kumar v. Cancer Chemother Pharmacol. 2022 Jun;89(6):737-750. doi: 10.1007/s00280-022-04429-z. Epub 2022 Apr 18. Cancer Chemother Pharmacol. 2022. PMID: 35435471
Incredible use of plant-derived bioactives as anticancer agents.
Kangra K, Kakkar S, Mittal V, Kumar V, Aggarwal N, Chopra H, Malik T, Garg V. Kangra K, et al. Among authors: kumar v. RSC Adv. 2025 Jan 20;15(3):1721-1746. doi: 10.1039/d4ra05089d. eCollection 2025 Jan 16. RSC Adv. 2025. PMID: 39835210 Free PMC article. Review.
Polymerase Eta Recruits FANCD2 to Common Fragile Sites to Maintain Genome Stability.
Niljikar M, Barreto-Galvez A, Patel S, Gagliardi JE, Kumar V, Pradeep A, Juwarwala A, Gerhardt J, Chang Y, Montagna C, Madireddy A. Niljikar M, et al. Among authors: kumar v. bioRxiv [Preprint]. 2025 Jan 8:2025.01.06.631600. doi: 10.1101/2025.01.06.631600. bioRxiv. 2025. PMID: 39829787 Free PMC article. Preprint.
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