Xiong XF - Search Results

1

Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule Gαq/11 inhibitors against uveal melanoma.

Deng JJ, Liu L, Ge Y, Song Z, Huang J, Fan G, Xiong XF. Deng JJ, et al. Among authors: xiong xf. Eur J Med Chem. 2022 Sep 5;239:114520. doi: 10.1016/j.ejmech.2022.114520. Epub 2022 Jun 11. Eur J Med Chem. 2022. PMID: 35716516

2

Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery.

Li J, Ge Y, Huang JX, Strømgaard K, Zhang X, Xiong XF. Li J, et al. Among authors: xiong xf. J Med Chem. 2020 May 28;63(10):5013-5030. doi: 10.1021/acs.jmedchem.9b01452. Epub 2019 Dec 26. J Med Chem. 2020. PMID: 31841625 Review.

3

Asymmetric Synthesis of Oxindole-Derived Vicinal Tetrasubstituted Acyclic Amino Acid Derivatives by the Mannich-Type Reaction.

Hou KQ, Zhou F, Chen XP, Ge Y, Chan ASC, Xiong XF. Hou KQ, et al. Among authors: xiong xf. J Org Chem. 2020 Aug 7;85(15):9661-9671. doi: 10.1021/acs.joc.0c00981. Epub 2020 Jul 10. J Org Chem. 2020. PMID: 32603113

4

Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies.

Song Z, Wang M, Ge Y, Chen XP, Xu Z, Sun Y, Xiong XF. Song Z, et al. Among authors: xiong xf. Acta Pharm Sin B. 2021 Jan;11(1):13-29. doi: 10.1016/j.apsb.2020.07.010. Epub 2020 Jul 26. Acta Pharm Sin B. 2021. PMID: 33532178 Free PMC article. Review.

5

Design, Synthesis, and Evaluation of Small Molecule Gαq/11 Protein Inhibitors for the Treatment of Uveal Melanoma.

Ge Y, Shi S, Deng JJ, Chen XP, Song Z, Liu L, Lou L, Zhang X, Xiong XF. Ge Y, et al. Among authors: xiong xf. J Med Chem. 2021 Mar 25;64(6):3131-3152. doi: 10.1021/acs.jmedchem.0c01977. Epub 2021 Mar 15. J Med Chem. 2021. PMID: 33715360

6

Silanol: a bifunctional group for peptide synthesis and late-stage functionalization.

Hu QL, Hou KQ, Li J, Ge Y, Song ZD, Chan ASC, Xiong XF. Hu QL, et al. Among authors: xiong xf. Chem Sci. 2020 Jun 3;11(23):6070-6074. doi: 10.1039/d0sc02439b. Chem Sci. 2020. PMID: 34094099 Free PMC article.

7

Cleavable and tunable cysteine-specific arylation modification with aryl thioethers.

Li J, Deng JJ, Yin Z, Hu QL, Ge Y, Song Z, Zhang Y, Chan ASC, Li H, Xiong XF. Li J, et al. Among authors: xiong xf. Chem Sci. 2021 Feb 18;12(14):5209-5215. doi: 10.1039/d0sc06576e. Chem Sci. 2021. PMID: 34168774 Free PMC article.

8

Exploring Marine-Derived Ascochlorins as Novel Human Dihydroorotate Dehydrogenase Inhibitors for Treatment of Triple-Negative Breast Cancer.

Luo X, Cai G, Guo Y, Gao C, Huang W, Zhang Z, Lu H, Liu K, Chen J, Xiong X, Lei J, Zhou X, Wang J, Liu Y. Luo X, et al. J Med Chem. 2021 Sep 23;64(18):13918-13932. doi: 10.1021/acs.jmedchem.1c01402. Epub 2021 Sep 13. J Med Chem. 2021. PMID: 34516133

9

Targeting mutated GTPase KRAS in tumor therapies.

Fan G, Lou L, Song Z, Zhang X, Xiong XF. Fan G, et al. Among authors: xiong xf. Eur J Med Chem. 2021 Dec 15;226:113816. doi: 10.1016/j.ejmech.2021.113816. Epub 2021 Sep 4. Eur J Med Chem. 2021. PMID: 34520956 Review.

10

Demethylative Alkylation of Methionine Residue by Employing the Sulfonium as the Key Intermediate.

Hu QL, Liu JT, Li J, Ge Y, Song Z, Chan ASC, Xiong XF. Hu QL, et al. Among authors: xiong xf. Org Lett. 2021 Nov 5;23(21):8543-8548. doi: 10.1021/acs.orglett.1c03241. Epub 2021 Oct 20. Org Lett. 2021. PMID: 34669410

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