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TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy.
Zhang L, Dietsche F, Seitaj B, Rojas-Charry L, Latchman N, Tomar D, Wüst RC, Nickel A, Frauenknecht KB, Schoser B, Schumann S, Schmeisser MJ, Vom Berg J, Buch T, Finger S, Wenzel P, Maack C, Elrod JW, Parys JB, Bultynck G, Methner A. Zhang L, et al. Among authors: wust rc. Life Sci Alliance. 2022 Jun 17;5(10):e202201478. doi: 10.26508/lsa.202201478. Print 2022 Oct. Life Sci Alliance. 2022. PMID: 35715207 Free PMC article.
The Antibiotic Doxycycline Impairs Cardiac Mitochondrial and Contractile Function.
Wüst RCI, Coolen BF, Held NM, Daal MRR, Alizadeh Tazehkandi V, Baks-Te Bulte L, Wiersma M, Kuster DWD, Brundel BJJM, van Weeghel M, Strijkers GJ, Houtkooper RH. Wüst RCI, et al. Int J Mol Sci. 2021 Apr 15;22(8):4100. doi: 10.3390/ijms22084100. Int J Mol Sci. 2021. PMID: 33921053 Free PMC article.
Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction.
Miranda-Silva D, Wüst RCI, Conceição G, Gonçalves-Rodrigues P, Gonçalves N, Gonçalves A, Kuster DWD, Leite-Moreira AF, van der Velden J, de Sousa Beleza JM, Magalhães J, Stienen GJM, Falcão-Pires I. Miranda-Silva D, et al. Acta Physiol (Oxf). 2020 Mar;228(3):e13378. doi: 10.1111/apha.13378. Epub 2019 Oct 10. Acta Physiol (Oxf). 2020. PMID: 31520455 Free PMC article.
Skeletal muscle mitochondrial fragmentation predicts age-associated decline in physical capacity.
Goulding RP, Charlton BT, Breedveld EA, van der Laan M, Strating AR, Noort W, Kolodyazhna A, Appelman B, van Vugt M, Grootemaat AE, van der Wel NN, de Koning JJ, Bloemers FW, Wüst RCI. Goulding RP, et al. Among authors: wust rci. Aging Cell. 2024 Dec 4:e14386. doi: 10.1111/acel.14386. Online ahead of print. Aging Cell. 2024. PMID: 39630001 Free article.
Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration.
Nollet EE, Duursma I, Rozenbaum A, Eggelbusch M, Wüst RCI, Schoonvelde SAC, Michels M, Jansen M, van der Wel NN, Bedi KC, Margulies KB, Nirschl J, Kuster DWD, van der Velden J. Nollet EE, et al. Eur Heart J. 2023 Apr 1;44(13):1170-1185. doi: 10.1093/eurheartj/ehad028. Eur Heart J. 2023. PMID: 36734059 Free PMC article.
85 results