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Chemical and biological folding contribute to temperature-sensitive DeltaF508 CFTR trafficking.
Wang X, Koulov AV, Kellner WA, Riordan JR, Balch WE. Wang X, et al. Among authors: balch we. Traffic. 2008 Nov;9(11):1878-93. doi: 10.1111/j.1600-0854.2008.00806.x. Epub 2008 Jul 30. Traffic. 2008. PMID: 18764821 Free PMC article.
Proteostasis (Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. ...We find that DeltaF508 export requires a local biological folding environment that is sensitive to heat/stress-inducible factors found in some cell typ …
Proteostasis (Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. ...We find tha …
Emergent properties of proteostasis in managing cystic fibrosis.
Balch WE, Roth DM, Hutt DM. Balch WE, et al. Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2):a004499. doi: 10.1101/cshperspect.a004499. Cold Spring Harb Perspect Biol. 2011. PMID: 21421917 Free PMC article. Review.
Cystic fibrosis (CF) is a consequence of defective recognition of the multimembrane spanning protein cystic fibrosis conductance transmembrane regulator (CFTR) by the protein homeostasis or proteostasis network (PN) (Hutt and Balch (2010). Like many variant proteins trigge …
Cystic fibrosis (CF) is a consequence of defective recognition of the multimembrane spanning protein cystic fibrosis conductance transmembra …
244 results