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Targeting cholesteryl ester accumulation in the heart improves cardiac insulin response.
Actis Dato V, Benitez-Amaro A, Garcia E, Claudi L, Lhoëst MTL, Iborra A, Escola-Gil JC, Guerra JM, Samouillan V, Enrich C, Chiabrando G, Llorente-Cortés V. Actis Dato V, et al. Biomed Pharmacother. 2022 Aug;152:113270. doi: 10.1016/j.biopha.2022.113270. Epub 2022 Jun 13. Biomed Pharmacother. 2022. PMID: 35709652 Free article.
Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting hepatic lipogenesis and white adipose tissue lipolysis and fatty acid uptake.
Cedó L, Santos D, Roglans N, Julve J, Pallarès V, Rivas-Urbina A, Llorente-Cortes V, Laguna JC, Blanco-Vaca F, Escolà-Gil JC. Cedó L, et al. PLoS One. 2017 Dec 15;12(12):e0189834. doi: 10.1371/journal.pone.0189834. eCollection 2017. PLoS One. 2017. PMID: 29244870 Free PMC article.
Human ApoA-I Overexpression Enhances Macrophage-Specific Reverse Cholesterol Transport but Fails to Prevent Inherited Diabesity in Mice.
Méndez-Lara KA, Farré N, Santos D, Rivas-Urbina A, Metso J, Sánchez-Quesada JL, Llorente-Cortes V, Errico TL, Lerma E, Jauhiainen M, Martín-Campos JM, Alonso N, Escolà-Gil JC, Blanco-Vaca F, Julve J. Méndez-Lara KA, et al. Int J Mol Sci. 2019 Feb 2;20(3):655. doi: 10.3390/ijms20030655. Int J Mol Sci. 2019. PMID: 30717414 Free PMC article.
Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity.
Benitez-Amaro A, Revuelta-López E, Bornachea O, Cedó L, Vea À, Herrero L, Roglans N, Soler-Botija C, de Gonzalo-Calvo D, Nasarre L, Camino-López S, García E, Mato E, Blanco-Vaca F, Bayes-Genis A, Sebastian D, Laguna JC, Serra D, Zorzano A, Escola-Gil JC, Llorente-Cortes V. Benitez-Amaro A, et al. Metabolism. 2020 May;106:154191. doi: 10.1016/j.metabol.2020.154191. Epub 2020 Feb 26. Metabolism. 2020. PMID: 32112822 Free article.
LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight From Mouse Models.
Cedó L, Metso J, Santos D, García-León A, Plana N, Sabate-Soler S, Rotllan N, Rivas-Urbina A, Méndez-Lara KA, Tondo M, Girona J, Julve J, Pallarès V, Benitez-Amaro A, Llorente-Cortes V, Pérez A, Gómez-Coronado D, Ruotsalainen AK, Levonen AL, Sanchez-Quesada JL, Masana L, Kovanen PT, Jauhiainen M, Lee-Rueckert M, Blanco-Vaca F, Escolà-Gil JC. Cedó L, et al. Circ Res. 2020 Aug 28;127(6):778-792. doi: 10.1161/CIRCRESAHA.119.316424. Epub 2020 Jun 4. Circ Res. 2020. PMID: 32495699
Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD.
Weber M, Mera P, Casas J, Salvador J, Rodríguez A, Alonso S, Sebastián D, Soler-Vázquez MC, Montironi C, Recalde S, Fucho R, Calderón-Domínguez M, Mir JF, Bartrons R, Escola-Gil JC, Sánchez-Infantes D, Zorzano A, Llorente-Cortes V, Casals N, Valentí V, Frühbeck G, Herrero L, Serra D. Weber M, et al. FASEB J. 2020 Sep;34(9):11816-11837. doi: 10.1096/fj.202000678R. Epub 2020 Jul 15. FASEB J. 2020. PMID: 32666604 Free article.
Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice.
Soler-Vázquez MC, Romero MDM, Todorcevic M, Delgado K, Calatayud C, Benitez-Amaro A, La Chica Lhoëst MT, Mera P, Zagmutt S, Bastías-Pérez M, Ibeas K, Casals N, Escolà-Gil JC, Llorente-Cortés V, Consiglio A, Serra D, Herrero L. Soler-Vázquez MC, et al. Metab Eng. 2023 May;77:256-272. doi: 10.1016/j.ymben.2023.04.010. Epub 2023 Apr 22. Metab Eng. 2023. PMID: 37088334 Free article.
Inhibitory Effects of LRP1-Based Immunotherapy on Cardiac Extracellular Matrix Biophysical Alterations Induced by Hypercholesterolemia.
Samouillan V, Garcia E, Benitez-Amaro A, La Chica Lhoëst MT, Dandurand J, Actis Dato V, Guerra JM, Escolà-Gil JC, Chiabrando G, Enrich C, Llorente-Cortes V. Samouillan V, et al. J Med Chem. 2023 May 11;66(9):6251-6262. doi: 10.1021/acs.jmedchem.2c02103. Epub 2023 Apr 28. J Med Chem. 2023. PMID: 37116069 Free PMC article.
149 results