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1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.
Lu Y, Mann CA, Nolan S, Collins JA, Parker E, Papa J, Vibhute S, Jahanbakhsh S, Thwaites M, Hufnagel D, Hazbón MH, Moreno J, Stedman TT, Wittum T, Wozniak DJ, Osheroff N, Yalowich JC, Mitton-Fry MJ. Lu Y, et al. Among authors: osheroff n. ACS Med Chem Lett. 2022 May 9;13(6):955-963. doi: 10.1021/acsmedchemlett.2c00111. eCollection 2022 Jun 9. ACS Med Chem Lett. 2022. PMID: 35707162 Free PMC article.
Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers.
Dunlap N, Salyard TLJ, Pathiranage AL, Stubblefield J, Pitts SL, Ashley RE, Osheroff N. Dunlap N, et al. Among authors: osheroff n. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5627-5629. doi: 10.1016/j.bmcl.2014.10.082. Epub 2014 Nov 1. Bioorg Med Chem Lett. 2014. PMID: 25466187 Free PMC article.
Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β.
Ortega JA, Arencibia JM, Minniti E, Byl JAW, Franco-Ulloa S, Borgogno M, Genna V, Summa M, Bertozzi SM, Bertorelli R, Armirotti A, Minarini A, Sissi C, Osheroff N, De Vivo M. Ortega JA, et al. Among authors: osheroff n. J Med Chem. 2020 Nov 12;63(21):12873-12886. doi: 10.1021/acs.jmedchem.0c00774. Epub 2020 Oct 20. J Med Chem. 2020. PMID: 33079544 Free PMC article.
1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases.
Collins JA, Osheroff N. Collins JA, et al. Among authors: osheroff n. Chem Res Toxicol. 2021 Apr 19;34(4):1082-1090. doi: 10.1021/acs.chemrestox.0c00492. Epub 2021 Mar 24. Chem Res Toxicol. 2021. PMID: 33760604 Free PMC article.
Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.
Govender P, Müller R, Singh K, Reddy V, Eyermann CJ, Fienberg S, Ghorpade SR, Koekemoer L, Myrick A, Schnappinger D, Engelhart C, Meshanni J, Byl JAW, Osheroff N, Singh V, Chibale K, Basarab GS. Govender P, et al. Among authors: osheroff n. J Med Chem. 2022 May 12;65(9):6903-6925. doi: 10.1021/acs.jmedchem.2c00266. Epub 2022 May 2. J Med Chem. 2022. PMID: 35500229 Free PMC article.
244 results