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Discovery of 1H-Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors.
Leśniak RK, Nichols RJ, Schonemann M, Zhao J, Gajera CR, Lam G, Nguyen KC, Langston JW, Smith M, Montine TJ. Leśniak RK, et al. Among authors: langston jw. ACS Med Chem Lett. 2022 May 23;13(6):981-988. doi: 10.1021/acsmedchemlett.2c00116. eCollection 2022 Jun 9. ACS Med Chem Lett. 2022. PMID: 35707141 Free PMC article.
LRRK2 dephosphorylation increases its ubiquitination.
Zhao J, Molitor TP, Langston JW, Nichols RJ. Zhao J, et al. Among authors: langston jw. Biochem J. 2015 Jul 1;469(1):107-20. doi: 10.1042/BJ20141305. Epub 2015 May 5. Biochem J. 2015. PMID: 25939886 Free PMC article.
Nonsteroidal Anti-inflammatory Use and LRRK2 Parkinson's Disease Penetrance.
San Luciano M, Tanner CM, Meng C, Marras C, Goldman SM, Lang AE, Tolosa E, Schüle B, Langston JW, Brice A, Corvol JC, Goldwurm S, Klein C, Brockman S, Berg D, Brockmann K, Ferreira JJ, Tazir M, Mellick GD, Sue CM, Hasegawa K, Tan EK, Bressman S, Saunders-Pullman R; Michael J. Fox Foundation LRRK2 Cohort Consortium. San Luciano M, et al. Among authors: langston jw. Mov Disord. 2020 Oct;35(10):1755-1764. doi: 10.1002/mds.28189. Epub 2020 Jul 14. Mov Disord. 2020. PMID: 32662532 Free PMC article.
Is PARKIN parkinsonism a cancer predisposition syndrome?
Schüle B, Byrne C, Rees L, Langston JW. Schüle B, et al. Among authors: langston jw. Neurol Genet. 2015 Oct 15;1(4):e31. doi: 10.1212/NXG.0000000000000031. eCollection 2015 Dec. Neurol Genet. 2015. PMID: 27066568 Free PMC article.
353 results