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Page 1
cGAS-STING drives the IL-6-dependent survival of chromosomally instable cancers.
Hong C, Schubert M, Tijhuis AE, Requesens M, Roorda M, van den Brink A, Ruiz LA, Bakker PL, van der Sluis T, Pieters W, Chen M, Wardenaar R, van der Vegt B, Spierings DCJ, de Bruyn M, van Vugt MATM, Foijer F. Hong C, et al. Among authors: requesens m. Nature. 2022 Jul;607(7918):366-373. doi: 10.1038/s41586-022-04847-2. Epub 2022 Jun 15. Nature. 2022. PMID: 35705809
Extracellular matrix proteins regulate NK cell function in peripheral tissues.
Bunting MD, Vyas M, Requesens M, Langenbucher A, Schiferle EB, Manguso RT, Lawrence MS, Demehri S. Bunting MD, et al. Among authors: requesens m. Sci Adv. 2022 Mar 18;8(11):eabk3327. doi: 10.1126/sciadv.abk3327. Epub 2022 Mar 16. Sci Adv. 2022. PMID: 35294229 Free PMC article.
Neoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I study.
Eerkens AL, Brummel K, Vledder A, Paijens ST, Requesens M, Loiero D, van Rooij N, Plat A, Haan FJ, Klok P, Yigit R, Roelofsen T, de Lange NM, Klomp R, Church D, Ter Elst A, Wardenaar R, Spierings D, Foijer F, Koelzer VH, Bosse T, Bart J, Jalving M, Reyners AKL, de Bruyn M, Nijman HW. Eerkens AL, et al. Among authors: requesens m. Nat Commun. 2024 Sep 3;15(1):7695. doi: 10.1038/s41467-024-52098-8. Nat Commun. 2024. PMID: 39227583 Free PMC article. Clinical Trial.
Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors.
Ważyńska MA, Butera R, Requesens M, Plat A, Zarganes-Tzitzikas T, Neochoritis CG, Plewka J, Skalniak L, Kocik-Krol J, Musielak B, Magiera-Mularz K, Rodriguez I, Blok SN, de Bruyn M, Nijman HW, Elsinga PH, Holak TA, Dömling A. Ważyńska MA, et al. Among authors: requesens m. J Med Chem. 2023 Jul 27;66(14):9577-9591. doi: 10.1021/acs.jmedchem.3c00254. Epub 2023 Jul 14. J Med Chem. 2023. PMID: 37450644 Free PMC article.