Melnyk RA - Search Results

1

Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells.

Icho S, Rujas E, Muthuraman K, Tam J, Liang H, Landreth S, Liao M, Falzarano D, Julien JP, Melnyk RA. Icho S, et al. Among authors: melnyk ra. Antimicrob Agents Chemother. 2022 Jul 19;66(7):e0043922. doi: 10.1128/aac.00439-22. Epub 2022 Jun 15. Antimicrob Agents Chemother. 2022. PMID: 35703551 Free PMC article.

2

Renin and prorenin activate pathways implicated in organ damage in human mesangial cells independent of angiotensin II production.

Melnyk RA, Tam J, Boie Y, Kennedy BP, Percival MD. Melnyk RA, et al. Am J Nephrol. 2009;30(3):232-43. doi: 10.1159/000220260. Epub 2009 May 19. Am J Nephrol. 2009. PMID: 19451703

3

Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore.

Zhang Z, Park M, Tam J, Auger A, Beilhartz GL, Lacy DB, Melnyk RA. Zhang Z, et al. Among authors: melnyk ra. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3721-6. doi: 10.1073/pnas.1400680111. Epub 2014 Feb 24. Proc Natl Acad Sci U S A. 2014. PMID: 24567384 Free PMC article.

4

Small molecule inhibitors of Clostridium difficile toxin B-induced cellular damage.

Tam J, Beilhartz GL, Auger A, Gupta P, Therien AG, Melnyk RA. Tam J, et al. Among authors: melnyk ra. Chem Biol. 2015 Feb 19;22(2):175-85. doi: 10.1016/j.chembiol.2014.12.010. Epub 2015 Jan 22. Chem Biol. 2015. PMID: 25619932

5

Small Molecules Take A Big Step Against Clostridium difficile.

Beilhartz GL, Tam J, Melnyk RA. Beilhartz GL, et al. Among authors: melnyk ra. Trends Microbiol. 2015 Dec;23(12):746-748. doi: 10.1016/j.tim.2015.10.009. Epub 2015 Nov 5. Trends Microbiol. 2015. PMID: 26547239

6

Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".

Beilhartz GL, Tam J, Zhang Z, Melnyk RA. Beilhartz GL, et al. Among authors: melnyk ra. Sci Transl Med. 2016 Dec 21;8(370):370tc2. doi: 10.1126/scitranslmed.aad8926. Sci Transl Med. 2016. PMID: 28003550

7

Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants.

Gupta P, Zhang Z, Sugiman-Marangos SN, Tam J, Raman S, Julien JP, Kroh HK, Lacy DB, Murgolo N, Bekkari K, Therien AG, Hernandez LD, Melnyk RA. Gupta P, et al. Among authors: melnyk ra. J Biol Chem. 2017 Oct 20;292(42):17290-17301. doi: 10.1074/jbc.M117.806687. Epub 2017 Aug 23. J Biol Chem. 2017. PMID: 28842504 Free PMC article.

8

Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota.

Tam J, Hamza T, Ma B, Chen K, Beilhartz GL, Ravel J, Feng H, Melnyk RA. Tam J, et al. Among authors: melnyk ra. Nat Commun. 2018 Dec 7;9(1):5233. doi: 10.1038/s41467-018-07705-w. Nat Commun. 2018. PMID: 30531960 Free PMC article.

9

Dismantling a Toxin to Disarm a Superbug.

Icho S, Melnyk RA. Icho S, et al. Among authors: melnyk ra. Trends Pharmacol Sci. 2019 Mar;40(3):155-156. doi: 10.1016/j.tips.2019.01.007. Epub 2019 Jan 23. Trends Pharmacol Sci. 2019. PMID: 30685063

10

Intestinal bile acids directly modulate the structure and function of C. difficile TcdB toxin.

Tam J, Icho S, Utama E, Orrell KE, Gómez-Biagi RF, Theriot CM, Kroh HK, Rutherford SA, Lacy DB, Melnyk RA. Tam J, et al. Among authors: melnyk ra. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6792-6800. doi: 10.1073/pnas.1916965117. Epub 2020 Mar 9. Proc Natl Acad Sci U S A. 2020. PMID: 32152097 Free PMC article.

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