Ortlund EA - Search Results

1

Lysosome lipid signalling from the periphery to neurons regulates longevity.

Savini M, Folick A, Lee YT, Jin F, Cuevas A, Tillman MC, Duffy JD, Zhao Q, Neve IA, Hu PW, Yu Y, Zhang Q, Ye Y, Mair WB, Wang J, Han L, Ortlund EA, Wang MC. Savini M, et al. Among authors: ortlund ea. Nat Cell Biol. 2022 Jun;24(6):906-916. doi: 10.1038/s41556-022-00926-8. Epub 2022 Jun 9. Nat Cell Biol. 2022. PMID: 35681008 Free PMC article.

2

The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits.

Mays SG, Hercules D, Ortlund EA, Okafor CD. Mays SG, et al. Among authors: ortlund ea. bioRxiv [Preprint]. 2023 Jan 28:2023.01.27.525934. doi: 10.1101/2023.01.27.525934. bioRxiv. 2023. Update in: Protein Sci. 2023 Oct;32(10):e4754. doi: 10.1002/pro.4754 PMID: 36747705 Free PMC article. Updated. Preprint.

3

Endurance Exercise Training Alters Lipidomic Profiles of Plasma and Eight Tissues in Rats: a MoTrPAC study.

Ortlund E, Hou Z, Chen CY, Gaul D, Zhang T, Moore S, Liu X, Ivanova A, Maner-Smith K, Newgard C, Bodine S, Savage E, Bennett A, Fernandez F. Ortlund E, et al. Res Sq [Preprint]. 2024 Nov 21:rs.3.rs-5263273. doi: 10.21203/rs.3.rs-5263273/v1. Res Sq. 2024. PMID: 39606465 Free PMC article. Preprint.

4

Integrative brain omics approach reveals key role for sn-1 lysophosphatidylethanolamine in Alzheimer's dementia.

Ortlund E, Chen CY, Maner-Smith K, Khadka M, Ahn J, Gulbin X, Ivanova A, Dammer E, Seyfried N, Bennett D, Hajjar I. Ortlund E, et al. Res Sq [Preprint]. 2024 Feb 27:rs.3.rs-3973736. doi: 10.21203/rs.3.rs-3973736/v1. Res Sq. 2024. PMID: 38464293 Free PMC article. Preprint.

5

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.

Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, Pathak MC, Ortlund EA, Moore DD. Lee JM, et al. Among authors: ortlund ea. Nature. 2011 May 25;474(7352):506-10. doi: 10.1038/nature10111. Nature. 2011. PMID: 21614002 Free PMC article.

6

Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.

Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC. Folick A, et al. Among authors: ortlund ea. Science. 2015 Jan 2;347(6217):83-6. doi: 10.1126/science.1258857. Science. 2015. PMID: 25554789 Free PMC article.

7

Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8.

Tillman MC, Khadka M, Duffy J, Wang MC, Ortlund EA. Tillman MC, et al. Among authors: ortlund ea. Sci Rep. 2019 Jul 10;9(1):9966. doi: 10.1038/s41598-019-46230-8. Sci Rep. 2019. PMID: 31292465 Free PMC article.

8

Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine.

Tillman MC, Imai N, Li Y, Khadka M, Okafor CD, Juneja P, Adhiyaman A, Hagen SJ, Cohen DE, Ortlund EA. Tillman MC, et al. Among authors: ortlund ea. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22080-22089. doi: 10.1073/pnas.2003877117. Epub 2020 Aug 20. Proc Natl Acad Sci U S A. 2020. PMID: 32820071 Free PMC article.

9

Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons.

Squires KE, Gerber KJ, Tillman MC, Lustberg DJ, Montañez-Miranda C, Zhao M, Ramineni S, Scharer CD, Saha RN, Shu FJ, Schroeder JP, Ortlund EA, Weinshenker D, Dudek SM, Hepler JR. Squires KE, et al. Among authors: ortlund ea. J Biol Chem. 2021 Jan-Jun;296:100024. doi: 10.1074/jbc.RA120.016009. Epub 2020 Nov 22. J Biol Chem. 2021. PMID: 33410399 Free PMC article.

10

Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice.

Li Y, Imai N, Nicholls HT, Roberts BR, Goyal S, Krisko TI, Ang LH, Tillman MC, Roberts AM, Baqai M, Ortlund EA, Cohen DE, Hagen SJ. Li Y, et al. Among authors: ortlund ea. Nat Commun. 2021 Jun 9;12(1):3493. doi: 10.1038/s41467-021-23595-x. Nat Commun. 2021. PMID: 34108467 Free PMC article.

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