Zhang X - Search Results

1

Tetrahydropyridin-4-ylpicolinoylglycines as novel and orally active prolyl hydroxylase 2 (PHD2) inhibitors for the treatment of renal anemia.

Su K, Li Z, Zhang L, Fang S, Mao M, Sun Z, Zhang X. Su K, et al. Among authors: zhang l, zhang x. Eur J Med Chem. 2022 Aug 5;238:114479. doi: 10.1016/j.ejmech.2022.114479. Epub 2022 May 25. Eur J Med Chem. 2022. PMID: 35675755

2

Studies on gambogic acid (IV): Exploring structure-activity relationship with IκB kinase-beta (IKKβ).

Sun H, Chen F, Wang X, Liu Z, Yang Q, Zhang X, Zhu J, Qiang L, Guo Q, You Q. Sun H, et al. Among authors: zhang x. Eur J Med Chem. 2012 May;51:110-23. doi: 10.1016/j.ejmech.2012.02.029. Epub 2012 Mar 3. Eur J Med Chem. 2012. PMID: 22472167

3

Garcinia xanthones as orally active antitumor agents.

Zhang X, Li X, Sun H, Wang X, Zhao L, Gao Y, Liu X, Zhang S, Wang Y, Yang Y, Zeng S, Guo Q, You Q. Zhang X, et al. Among authors: zhang s. J Med Chem. 2013 Jan 10;56(1):276-92. doi: 10.1021/jm301593r. Epub 2012 Dec 31. J Med Chem. 2013. PMID: 23167526

4

Novel IKKβ inhibitors discovery based on the co-crystal structure by using binding-conformation-based and ligand-based method.

Huang JJ, Wu XW, Jia JM, Guo XK, Xue X, Jiang ZY, Zhang SL, Zhang XJ, Sun HP, You QD. Huang JJ, et al. Among authors: zhang sl, zhang xj. Eur J Med Chem. 2013 May;63:269-78. doi: 10.1016/j.ejmech.2013.01.045. Epub 2013 Feb 17. Eur J Med Chem. 2013. PMID: 23501112

5

3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.

Xi MY, Jia JM, Sun HP, Sun ZY, Jiang JW, Wang YJ, Zhang MY, Zhu JF, Xu LL, Jiang ZY, Xue X, Ye M, Yang X, Gao Y, Tao L, Guo XK, Xu XL, Guo QL, Zhang XJ, Hu R, You QD. Xi MY, et al. Among authors: zhang my, zhang xj. J Med Chem. 2013 Oct 24;56(20):7925-38. doi: 10.1021/jm400944k. Epub 2013 Oct 9. J Med Chem. 2013. PMID: 24053646

6

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.

Jiang ZY, Lu MC, Xu LL, Yang TT, Xi MY, Xu XL, Guo XK, Zhang XJ, You QD, Sun HP. Jiang ZY, et al. J Med Chem. 2014 Mar 27;57(6):2736-45. doi: 10.1021/jm5000529. Epub 2014 Feb 21. J Med Chem. 2014. PMID: 24512214

7

Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I).

Guo X, Ma X, Yang Q, Xu J, Huang L, Jia J, Shan J, Liu L, Chen W, Chu H, Wei J, Zhang X, Sun H, Tang Y, You Q. Guo X, et al. Among authors: zhang x. Eur J Med Chem. 2014 Jun 23;81:89-94. doi: 10.1016/j.ejmech.2014.03.075. Epub 2014 Mar 28. Eur J Med Chem. 2014. PMID: 24824064

8

2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1).

Bian J, Deng B, Xu L, Xu X, Wang N, Hu T, Yao Z, Du J, Yang L, Lei Y, Li X, Sun H, Zhang X, You Q. Bian J, et al. Among authors: zhang x. Eur J Med Chem. 2014 Jul 23;82:56-67. doi: 10.1016/j.ejmech.2014.05.041. Epub 2014 May 14. Eur J Med Chem. 2014. PMID: 24874653

9

Novel natural-product-like caged xanthones with improved druglike properties and in vivo antitumor potency.

Wu Y, Hu M, Yang L, Li X, Bian J, Jiang F, Sun H, You Q, Zhang X. Wu Y, et al. Among authors: zhang x. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2584-8. doi: 10.1016/j.bmcl.2015.04.031. Epub 2015 Apr 18. Bioorg Med Chem Lett. 2015. PMID: 25958244

10

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Xu LL, Zhu JF, Xu XL, Zhu J, Li L, Xi MY, Jiang ZY, Zhang MY, Liu F, Lu MC, Bao QC, Li Q, Zhang C, Wei JL, Zhang XJ, Zhang LS, You QD, Sun HP. Xu LL, et al. J Med Chem. 2015 Jul 23;58(14):5419-36. doi: 10.1021/acs.jmedchem.5b00170. Epub 2015 Jul 7. J Med Chem. 2015. PMID: 26111355

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