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The SARS-CoV-2 spike protein binds and modulates estrogen receptors.
Solis O, Beccari AR, Iaconis D, Talarico C, Ruiz-Bedoya CA, Nwachukwu JC, Cimini A, Castelli V, Bertini R, Montopoli M, Cocetta V, Borocci S, Prandi IG, Flavahan K, Bahr M, Napiorkowski A, Chillemi G, Ooka M, Yang X, Zhang S, Xia M, Zheng W, Bonaventura J, Pomper MG, Hooper JE, Morales M, Rosenberg AZ, Nettles KW, Jain SK, Allegretti M, Michaelides M. Solis O, et al. Among authors: nwachukwu jc. bioRxiv [Preprint]. 2022 May 23:2022.05.21.492920. doi: 10.1101/2022.05.21.492920. bioRxiv. 2022. Update in: Sci Adv. 2022 Dec 2;8(48):eadd4150. doi: 10.1126/sciadv.add4150 PMID: 35665018 Free PMC article. Updated. Preprint.
First-trimester trophoblast cell model gene response to hypoxia.
Koklanaris N, Nwachukwu JC, Huang SJ, Guller S, Karpisheva K, Garabedian M, Lee MJ. Koklanaris N, et al. Among authors: nwachukwu jc. Am J Obstet Gynecol. 2006 Mar;194(3):687-93. doi: 10.1016/j.ajog.2006.01.067. Am J Obstet Gynecol. 2006. PMID: 16522398
Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP.
Mita P, Savas JN, Djouder N, Yates JR 3rd, Ha S, Ruoff R, Schafler ED, Nwachukwu JC, Tanese N, Cowan NJ, Zavadil J, Garabedian MJ, Logan SK. Mita P, et al. Among authors: nwachukwu jc. Mol Cell Biol. 2011 Sep;31(17):3639-52. doi: 10.1128/MCB.05429-11. Epub 2011 Jul 5. Mol Cell Biol. 2011. PMID: 21730289 Free PMC article.
Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands.
Zheng Y, Zhu M, Srinivasan S, Nwachukwu JC, Cavett V, Min J, Carlson KE, Wang P, Dong C, Katzenellenbogen JA, Nettles KW, Zhou HB. Zheng Y, et al. Among authors: nwachukwu jc. ChemMedChem. 2012 Jun;7(6):1094-100. doi: 10.1002/cmdc.201200048. Epub 2012 Apr 19. ChemMedChem. 2012. PMID: 22517684 Free PMC article.
Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides.
Zhu M, Zhang C, Nwachukwu JC, Srinivasan S, Cavett V, Zheng Y, Carlson KE, Dong C, Katzenellenbogen JA, Nettles KW, Zhou HB. Zhu M, et al. Among authors: nwachukwu jc. Org Biomol Chem. 2012 Nov 21;10(43):8692-700. doi: 10.1039/c2ob26531a. Org Biomol Chem. 2012. PMID: 23033157 Free PMC article.
42 results