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A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding.
Yang J, Lin S, Sun H, Chen Z, Yang F, Lin X, Guo L, Wang L, Wen A, Zhang X, Dai Y, He B, Cao Y, Dong H, Liu X, Chen B, Li J, Zhao Q, Lu G. Yang J, et al. Among authors: dong h. Front Immunol. 2022 May 18;13:820336. doi: 10.3389/fimmu.2022.820336. eCollection 2022. Front Immunol. 2022. PMID: 35663966 Free PMC article.
Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells.
Hong W, Yang J, Zou J, Bi Z, He C, Lei H, He X, Li X, Alu A, Ren W, Wang Z, Jiang X, Zhong K, Jia G, Yang Y, Yu W, Huang Q, Yang M, Zhou Y, Zhao Y, Kuang D, Wang J, Wang H, Chen S, Luo M, Zhang Z, Lu T, Chen L, Que H, He Z, Sun Q, Wang W, Shen G, Lu G, Zhao Z, Yang L, Yang J, Wang Z, Li J, Song X, Dai L, Chen C, Geng J, Gou M, Chen L, Dong H, Peng Y, Huang C, Qian Z, Cheng W, Fan C, Wei Y, Su Z, Tong A, Lu S, Peng X, Wei X. Hong W, et al. Among authors: dong h. Cell Mol Immunol. 2022 May;19(5):577-587. doi: 10.1038/s41423-022-00845-6. Epub 2022 Mar 10. Cell Mol Immunol. 2022. PMID: 35273357 Free PMC article.
An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry.
Lin X, Guo L, Lin S, Chen Z, Yang F, Yang J, Wang L, Wen A, Duan Y, Zhang X, Dai Y, Yin K, Yuan X, Yu C, He B, Cao Y, Dong H, Li J, Zhao Q, Lu G. Lin X, et al. Among authors: dong h. Emerg Microbes Infect. 2022 Dec;11(1):1920-1935. doi: 10.1080/22221751.2022.2095308. Emerg Microbes Infect. 2022. PMID: 35757908 Free PMC article.
Structural basis of BAM-mediated outer membrane β-barrel protein assembly.
Shen C, Chang S, Luo Q, Chan KC, Zhang Z, Luo B, Xie T, Lu G, Zhu X, Wei X, Dong C, Zhou R, Zhang X, Tang X, Dong H. Shen C, et al. Among authors: dong c, dong h. Nature. 2023 May;617(7959):185-193. doi: 10.1038/s41586-023-05988-8. Epub 2023 Apr 26. Nature. 2023. PMID: 37100902
Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants.
Lei H, Hong W, Yang J, He C, Zhou Y, Zhang Y, Alu A, Shi J, Liu J, Qin F, Ao D, Huang X, Chen Z, Yang H, Yang Y, Yu W, Tang C, Wang J, Li B, Huang Q, Hu H, Cheng W, Dong H, Lei J, Chen L, Zhou X, Li J, Yang L, Wang Z, Wang W, Shen G, Yang J, Zhao Z, Song X, Lu G, Sun Q, Wang Y, Lu S, Wei X. Lei H, et al. Among authors: dong h. Signal Transduct Target Ther. 2024 Nov 20;9(1):311. doi: 10.1038/s41392-024-02025-6. Signal Transduct Target Ther. 2024. PMID: 39562542 Free PMC article.
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE.
Qiao W, Shen C, Chen Y, Chang S, Wang X, Yang L, Pang J, Luo Q, Zhang Z, Xiang Y, Zhao C, Lu G, Ding BS, Ying B, Tang X, Dong H. Qiao W, et al. Among authors: dong h. Signal Transduct Target Ther. 2024 Dec 27;9(1):354. doi: 10.1038/s41392-024-02067-w. Signal Transduct Target Ther. 2024. PMID: 39725716 Free PMC article.
Structural basis for bacterial lipoprotein relocation by the transporter LolCDE.
Tang X, Chang S, Zhang K, Luo Q, Zhang Z, Wang T, Qiao W, Wang C, Shen C, Zhang Z, Zhu X, Wei X, Dong C, Zhang X, Dong H. Tang X, et al. Among authors: dong c, dong h. Nat Struct Mol Biol. 2021 Apr;28(4):347-355. doi: 10.1038/s41594-021-00573-x. Epub 2021 Mar 29. Nat Struct Mol Biol. 2021. PMID: 33782615
Structural basis of negative regulation of CRISPR-Cas7-11 by TPR-CHAT.
Hong T, Luo Q, Ma H, Wang X, Li X, Shen C, Pang J, Wang Y, Chen Y, Zhang C, Su Z, Dong H, Tang X. Hong T, et al. Among authors: dong h. Signal Transduct Target Ther. 2024 May 13;9(1):111. doi: 10.1038/s41392-024-01821-4. Signal Transduct Target Ther. 2024. PMID: 38735995 Free PMC article.
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