O'Brien EP - Search Results

1

Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and less functional.

Nissley DA, Jiang Y, Trovato F, Sitarik I, Narayan KB, To P, Xia Y, Fried SD, O'Brien EP. Nissley DA, et al. Nat Commun. 2022 Jun 2;13(1):3081. doi: 10.1038/s41467-022-30548-5. Nat Commun. 2022. PMID: 35654797 Free PMC article.

2

Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates.

O'Brien EP, Vendruscolo M, Dobson CM. O'Brien EP, et al. Nat Commun. 2014;5:2988. doi: 10.1038/ncomms3988. Nat Commun. 2014. PMID: 24394622 Free article.

3

Timing is everything: unifying codon translation rates and nascent proteome behavior.

Nissley DA, O'Brien EP. Nissley DA, et al. J Am Chem Soc. 2014 Dec 31;136(52):17892-8. doi: 10.1021/ja510082j. Epub 2014 Dec 19. J Am Chem Soc. 2014. PMID: 25486504 Review.

4

Cotranslational Protein Folding inside the Ribosome Exit Tunnel.

Nilsson OB, Hedman R, Marino J, Wickles S, Bischoff L, Johansson M, Müller-Lucks A, Trovato F, Puglisi JD, O'Brien EP, Beckmann R, von Heijne G. Nilsson OB, et al. Cell Rep. 2015 Sep 8;12(10):1533-40. doi: 10.1016/j.celrep.2015.07.065. Epub 2015 Aug 28. Cell Rep. 2015. PMID: 26321634 Free PMC article.

5

Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding.

Nissley DA, Sharma AK, Ahmed N, Friedrich UA, Kramer G, Bukau B, O'Brien EP. Nissley DA, et al. Nat Commun. 2016 Feb 18;7:10341. doi: 10.1038/ncomms10341. Nat Commun. 2016. PMID: 26887592 Free PMC article.

6

Insights into Cotranslational Nascent Protein Behavior from Computer Simulations.

Trovato F, O'Brien EP. Trovato F, et al. Annu Rev Biophys. 2016 Jul 5;45:345-69. doi: 10.1146/annurev-biophys-070915-094153. Epub 2016 May 23. Annu Rev Biophys. 2016. PMID: 27297399 Review.

7

Altered Co-Translational Processing Plays a Role in Huntington's Pathogenesis-A Hypothesis.

Nissley DA, O'Brien EP. Nissley DA, et al. Front Mol Neurosci. 2016 Jul 6;9:54. doi: 10.3389/fnmol.2016.00054. eCollection 2016. Front Mol Neurosci. 2016. PMID: 27458341 Free PMC article.

8

Fast Protein Translation Can Promote Co- and Posttranslational Folding of Misfolding-Prone Proteins.

Trovato F, O'Brien EP. Trovato F, et al. Biophys J. 2017 May 9;112(9):1807-1819. doi: 10.1016/j.bpj.2017.04.006. Biophys J. 2017. PMID: 28494952 Free PMC article.

9

Increasing Protein Production Rates Can Decrease the Rate at Which Functional Protein Is Produced and Their Steady-State Levels.

Sharma AK, O'Brien EP. Sharma AK, et al. J Phys Chem B. 2017 Jul 20;121(28):6775-6784. doi: 10.1021/acs.jpcb.7b01700. Epub 2017 Jul 7. J Phys Chem B. 2017. PMID: 28650169

10

Non-equilibrium coupling of protein structure and function to translation-elongation kinetics.

Sharma AK, O'Brien EP. Sharma AK, et al. Curr Opin Struct Biol. 2018 Apr;49:94-103. doi: 10.1016/j.sbi.2018.01.005. Epub 2018 Feb 3. Curr Opin Struct Biol. 2018. PMID: 29414517 Review.

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