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Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain.
Sherrill LM, Joya EE, Walker A, Roy A, Alhammad YM, Atobatele M, Wazir S, Abbas G, Keane P, Zhuo J, Leung AKL, Johnson DK, Lehtiö L, Fehr AR, Ferraris D. Sherrill LM, et al. Among authors: leung akl. Bioorg Med Chem. 2022 Aug 1;67:116788. doi: 10.1016/j.bmc.2022.116788. Epub 2022 May 11. Bioorg Med Chem. 2022. PMID: 35597097 Free PMC article.
ADPr-ChAP: Mapping ADP-Ribosylation onto the Genome.
McPherson RL, Leung AKL. McPherson RL, et al. Among authors: leung akl. Mol Cell. 2016 Feb 4;61(3):327-328. doi: 10.1016/j.molcel.2016.01.023. Mol Cell. 2016. PMID: 26849191 Free article.
ADPriboDB 2.0: an updated database of ADP-ribosylated proteins.
Ayyappan V, Wat R, Barber C, Vivelo CA, Gauch K, Visanpattanasin P, Cook G, Sazeides C, Leung AKL. Ayyappan V, et al. Among authors: leung akl. Nucleic Acids Res. 2021 Jan 8;49(D1):D261-D265. doi: 10.1093/nar/gkaa941. Nucleic Acids Res. 2021. PMID: 33137182 Free PMC article.
ADP-ribosyltransferases, an update on function and nomenclature.
Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, Filippov DV, Gagné JP, Grimaldi G, Guettler S, Hoch NC, Hottiger MO, Korn P, Kraus WL, Ladurner A, Lehtiö L, Leung AKL, Lord CJ, Mangerich A, Matic I, Matthews J, Moldovan GL, Moss J, Natoli G, Nielsen ML, Niepel M, Nolte F, Pascal J, Paschal BM, Pawłowski K, Poirier GG, Smith S, Timinszky G, Wang ZQ, Yélamos J, Yu X, Zaja R, Ziegler M. Lüscher B, et al. Among authors: leung akl. FEBS J. 2022 Dec;289(23):7399-7410. doi: 10.1111/febs.16142. Epub 2021 Sep 13. FEBS J. 2022. PMID: 34323016 Free PMC article.
High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain.
Dasovich M, Zhuo J, Goodman JA, Thomas A, McPherson RL, Jayabalan AK, Busa VF, Cheng SJ, Murphy BA, Redinger KR, Alhammad YMO, Fehr AR, Tsukamoto T, Slusher BS, Bosch J, Wei H, Leung AKL. Dasovich M, et al. Among authors: leung akl. ACS Chem Biol. 2022 Jan 21;17(1):17-23. doi: 10.1021/acschembio.1c00721. Epub 2021 Dec 14. ACS Chem Biol. 2022. PMID: 34904435
Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening.
Roy A, Alhammad YM, McDonald P, Johnson DK, Zhuo J, Wazir S, Ferraris D, Lehtiö L, Leung AKL, Fehr AR. Roy A, et al. Among authors: leung akl. bioRxiv [Preprint]. 2022 Mar 2:2022.03.01.482536. doi: 10.1101/2022.03.01.482536. bioRxiv. 2022. Update in: Antiviral Res. 2022 Jul;203:105344. doi: 10.1016/j.antiviral.2022.105344. PMID: 35262075 Free PMC article. Updated. Preprint.
138 results