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Page 1
Altered CXCR4 dynamics at the cell membrane impairs directed cell migration in WHIM syndrome patients.
García-Cuesta EM, Rodríguez-Frade JM, Gardeta SR, D'Agostino G, Martínez P, Soler Palacios B, Cascio G, Wolf T, Mateos N, Ayala-Bueno R, Santiago CA, Lucas P, Llorente L, Allende LM, González-Granado LI, Martín-Cófreces N, Roda-Navarro P, Sallusto F, Sánchez-Madrid F, García-Parajo MF, Martínez-Muñoz L, Mellado M. García-Cuesta EM, et al. Among authors: santiago ca. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2119483119. doi: 10.1073/pnas.2119483119. Epub 2022 May 19. Proc Natl Acad Sci U S A. 2022. PMID: 35588454 Free PMC article.
CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface.
Martínez-Muñoz L, Barroso R, Dyrhaug SY, Navarro G, Lucas P, Soriano SF, Vega B, Costas C, Muñoz-Fernández MÁ, Santiago C, Rodríguez Frade JM, Franco R, Mellado M. Martínez-Muñoz L, et al. Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1960-9. doi: 10.1073/pnas.1322887111. Epub 2014 Apr 28. Proc Natl Acad Sci U S A. 2014. PMID: 24778234 Free PMC article.
Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4.
Collins PJ, McCully ML, Martínez-Muñoz L, Santiago C, Wheeldon J, Caucheteux S, Thelen S, Cecchinato V, Laufer JM, Purvanov V, Monneau YR, Lortat-Jacob H, Legler DF, Uguccioni M, Thelen M, Piguet V, Mellado M, Moser B. Collins PJ, et al. FASEB J. 2017 Jul;31(7):3084-3097. doi: 10.1096/fj.201700013R. Epub 2017 Mar 30. FASEB J. 2017. PMID: 28360196 Free PMC article.
CXCL14 did not activate CXCR4-expressing cells (i.e., failed to trigger chemotaxis and Ca(2+) mobilization, as well as signaling via ERK1/2 and the small GTPase Rac1); however, CXCL14 bound to CXCR4 with high affinity, induced redistribution of cell-surface CXCR4, and enha …
CXCL14 did not activate CXCR4-expressing cells (i.e., failed to trigger chemotaxis and Ca(2+) mobilization, as well as signaling via …
Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function.
Martínez-Muñoz L, Rodríguez-Frade JM, Barroso R, Sorzano CÓS, Torreño-Pina JA, Santiago CA, Manzo C, Lucas P, García-Cuesta EM, Gutierrez E, Barrio L, Vargas J, Cascio G, Carrasco YR, Sánchez-Madrid F, García-Parajo MF, Mellado M. Martínez-Muñoz L, et al. Among authors: santiago ca. Mol Cell. 2018 Apr 5;70(1):106-119.e10. doi: 10.1016/j.molcel.2018.02.034. Mol Cell. 2018. PMID: 29625032 Free article.
Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function.
Martínez-Muñoz L, Rodríguez-Frade JM, Barroso R, Sorzano CÓS, Torreño-Pina JA, Santiago CA, Manzo C, Lucas P, García-Cuesta EM, Gutierrez E, Barrio L, Vargas J, Cascio G, Carrasco YR, Sánchez-Madrid F, García-Parajo MF, Mellado M. Martínez-Muñoz L, et al. Among authors: santiago ca. Mol Cell. 2018 Sep 6;71(5):873. doi: 10.1016/j.molcel.2018.08.012. Mol Cell. 2018. PMID: 30193101 Free article. No abstract available.
The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases.
García-Cuesta EM, Santiago CA, Vallejo-Díaz J, Juarranz Y, Rodríguez-Frade JM, Mellado M. García-Cuesta EM, et al. Among authors: santiago ca. Front Endocrinol (Lausanne). 2019 Aug 27;10:585. doi: 10.3389/fendo.2019.00585. eCollection 2019. Front Endocrinol (Lausanne). 2019. PMID: 31507535 Free PMC article. Review.
Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain.
García-Cuesta EM, Martínez P, Selvaraju K, Ulltjärn G, Gómez Pozo AM, D'Agostino G, Gardeta S, Quijada-Freire A, Blanco Gabella P, Roca C, Hoyo DD, Jiménez-Saiz R, García-Rubia A, Soler Palacios B, Lucas P, Ayala-Bueno R, Santander Acerete N, Carrasco Y, Oscar Sorzano C, Martinez A, Campillo NE, Jensen LD, Rodriguez Frade JM, Santiago C, Mellado M. García-Cuesta EM, et al. Elife. 2024 Sep 9;13:RP93968. doi: 10.7554/eLife.93968. Elife. 2024. PMID: 39248648 Free PMC article.
High mobility group box 1 orchestrates tissue regeneration via CXCR4.
Tirone M, Tran NL, Ceriotti C, Gorzanelli A, Canepari M, Bottinelli R, Raucci A, Di Maggio S, Santiago C, Mellado M, Saclier M, François S, Careccia G, He M, De Marchis F, Conti V, Ben Larbi S, Cuvellier S, Casalgrandi M, Preti A, Chazaud B, Al-Abed Y, Messina G, Sitia G, Brunelli S, Bianchi ME, Vénéreau E. Tirone M, et al. J Exp Med. 2018 Jan 2;215(1):303-318. doi: 10.1084/jem.20160217. Epub 2017 Dec 4. J Exp Med. 2018. PMID: 29203538 Free PMC article.
42 results