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The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.
Beckmann JS, Siripurapu KB, Nickell JR, Horton DB, Denehy ED, Vartak A, Crooks PA, Dwoskin LP, Bardo MT. Beckmann JS, et al. Among authors: denehy ed. J Pharmacol Exp Ther. 2010 Dec;335(3):841-51. doi: 10.1124/jpet.110.172742. Epub 2010 Aug 30. J Pharmacol Exp Ther. 2010. PMID: 20805303 Free PMC article.
Searching for Synthetic Opioid Rescue Agents: Identification of a Potent Opioid Agonist with Reduced Respiratory Depression.
Vu LY, Luo D, Johnson K, Denehy ED, Songrady JC, Martin J, Trivedi R, Alsum AR, Shaykin JD, Chaudhary CL, Woloshin EJ, Kornberger L, Bhuiyan N, Parkin S, Jiang Q, Che T, Alilain W, Turner JR, Bardo MT, Prisinzano TE. Vu LY, et al. Among authors: denehy ed. J Med Chem. 2024 Jun 13;67(11):9173-9193. doi: 10.1021/acs.jmedchem.4c00333. Epub 2024 May 29. J Med Chem. 2024. PMID: 38810170
Behavioral and genetic markers of susceptibility to escalate fentanyl intake.
Keady J, Charnigo R, Shaykin JD, Prantzalos E, Xia M, Denehy E, Bumgardner C, Miller J, Ortinski P, Bardo MT, Turner JR. Keady J, et al. bioRxiv [Preprint]. 2024 Dec 12:2024.12.06.627259. doi: 10.1101/2024.12.06.627259. bioRxiv. 2024. PMID: 39713469 Free PMC article. Preprint.
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