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Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer.
Jahid S, Ortega JA, Vuong LM, Acquistapace IM, Hachey SJ, Flesher JL, La Serra MA, Brindani N, La Sala G, Manigrasso J, Arencibia JM, Bertozzi SM, Summa M, Bertorelli R, Armirotti A, Jin R, Liu Z, Chen CF, Edwards R, Hughes CCW, De Vivo M, Ganesan AK. Jahid S, et al. Among authors: ganesan ak. Cell Rep. 2022 Apr 26;39(4):110760. doi: 10.1016/j.celrep.2022.110760. Cell Rep. 2022. PMID: 35476990 Free PMC article. No abstract available.
Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer.
Jahid S, Ortega JA, Vuong LM, Acquistapace IM, Hachey SJ, Flesher JL, La Serra MA, Brindani N, La Sala G, Manigrasso J, Arencibia JM, Bertozzi SM, Summa M, Bertorelli R, Armirotti A, Jin R, Liu Z, Chen CF, Edwards R, Hughes CCW, De Vivo M, Ganesan AK. Jahid S, et al. Among authors: ganesan ak. Cell Rep. 2022 Apr 5;39(1):110641. doi: 10.1016/j.celrep.2022.110641. Cell Rep. 2022. PMID: 35385746 Free PMC article.
Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer.
Brindani N, Vuong LM, Acquistapace IM, La Serra MA, Ortega JA, Veronesi M, Bertozzi SM, Summa M, Girotto S, Bertorelli R, Armirotti A, Ganesan AK, De Vivo M. Brindani N, et al. Among authors: ganesan ak. J Med Chem. 2023 Apr 27;66(8):5981-6001. doi: 10.1021/acs.jmedchem.3c00276. Epub 2023 Apr 7. J Med Chem. 2023. PMID: 37026468 Free PMC article.
Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy.
Brindani N, Vuong LM, La Serra MA, Salvador N, Menichetti A, Acquistapace IM, Ortega JA, Veronesi M, Bertozzi SM, Summa M, Girotto S, Bertorelli R, Armirotti A, Ganesan AK, De Vivo M. Brindani N, et al. Among authors: ganesan ak. J Med Chem. 2024 Jun 27;67(12):10401-10424. doi: 10.1021/acs.jmedchem.4c00855. Epub 2024 Jun 12. J Med Chem. 2024. PMID: 38866385 Free PMC article.
PIKfyve regulates melanosome biogenesis.
Liggins MC, Flesher JL, Jahid S, Vasudeva P, Eby V, Takasuga S, Sasaki J, Sasaki T, Boissy RE, Ganesan AK. Liggins MC, et al. Among authors: ganesan ak. PLoS Genet. 2018 Mar 27;14(3):e1007290. doi: 10.1371/journal.pgen.1007290. eCollection 2018 Mar. PLoS Genet. 2018. PMID: 29584722 Free PMC article.
Delineating the role of MITF isoforms in pigmentation and tissue homeostasis.
Flesher JL, Paterson-Coleman EK, Vasudeva P, Ruiz-Vega R, Marshall M, Pearlman E, MacGregor GR, Neumann J, Ganesan AK. Flesher JL, et al. Among authors: ganesan ak. Pigment Cell Melanoma Res. 2020 Mar;33(2):279-292. doi: 10.1111/pcmr.12828. Epub 2019 Oct 16. Pigment Cell Melanoma Res. 2020. PMID: 31562697 Free PMC article.
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