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Affinity improvement of a therapeutic antibody by structure-based computational design: generation of electrostatic interactions in the transition state stabilizes the antibody-antigen complex.
Kiyoshi M, Caaveiro JM, Miura E, Nagatoishi S, Nakakido M, Soga S, Shirai H, Kawabata S, Tsumoto K. Kiyoshi M, et al. Among authors: tsumoto k. PLoS One. 2014 Jan 27;9(1):e87099. doi: 10.1371/journal.pone.0087099. eCollection 2014. PLoS One. 2014. PMID: 24475232 Free PMC article.
Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses.
Nakayama T, Mizohata E, Yamashita T, Nagatoishi S, Nakakido M, Iwanari H, Mochizuki Y, Kado Y, Yokota Y, Satoh R, Tsumoto K, Fujitani H, Kodama T, Hamakubo T, Inoue T. Nakayama T, et al. Among authors: tsumoto k. Protein Sci. 2015 Mar;24(3):328-40. doi: 10.1002/pro.2619. Epub 2015 Jan 13. Protein Sci. 2015. PMID: 25492858 Free PMC article.
511 results