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Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets.
DiGruccio MR, Mawla AM, Donaldson CJ, Noguchi GM, Vaughan J, Cowing-Zitron C, van der Meulen T, Huising MO. DiGruccio MR, et al. Among authors: huising mo. Mol Metab. 2016 May 3;5(7):449-458. doi: 10.1016/j.molmet.2016.04.007. eCollection 2016 Jul. Mol Metab. 2016. PMID: 27408771 Free PMC article.
Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets.
van der Meulen T, Mawla AM, DiGruccio MR, Adams MW, Nies V, Dólleman S, Liu S, Ackermann AM, Cáceres E, Hunter AE, Kaestner KH, Donaldson CJ, Huising MO. van der Meulen T, et al. Among authors: huising mo. Cell Metab. 2017 Apr 4;25(4):911-926.e6. doi: 10.1016/j.cmet.2017.03.017. Cell Metab. 2017. PMID: 28380380 Free PMC article.
Artemether Does Not Turn α Cells into β Cells.
van der Meulen T, Lee S, Noordeloos E, Donaldson CJ, Adams MW, Noguchi GM, Mawla AM, Huising MO. van der Meulen T, et al. Among authors: huising mo. Cell Metab. 2018 Jan 9;27(1):218-225.e4. doi: 10.1016/j.cmet.2017.10.002. Epub 2017 Nov 2. Cell Metab. 2018. PMID: 29103923 Free PMC article.
Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic β-cell dysfunction and loss.
Koike S, Hsu MF, Bettaieb A, Chu B, Matsumoto N, Morisseau C, Havel PJ, Huising MO, Hammock BD, Haj FG. Koike S, et al. Among authors: huising mo. Free Radic Biol Med. 2021 Aug 20;172:48-57. doi: 10.1016/j.freeradbiomed.2021.05.029. Epub 2021 May 24. Free Radic Biol Med. 2021. PMID: 34038767 Free PMC article.
IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes.
Blencowe M, Furterer A, Wang Q, Gao F, Rosenberger M, Pei L, Nomoto H, Mawla AM, Huising MO, Coppola G, Yang X, Butler PC, Gurlo T. Blencowe M, et al. Among authors: huising mo. Diabetologia. 2022 Jan;65(1):173-187. doi: 10.1007/s00125-021-05569-2. Epub 2021 Sep 23. Diabetologia. 2022. PMID: 34554282 Free PMC article.
Dynamic Ins2 Gene Activity Defines β-Cell Maturity States.
Chu CMJ, Modi H, Ellis C, Krentz NAJ, Skovsø S, Zhao YB, Cen H, Noursadeghi N, Panzhinskiy E, Hu X, Dionne DA, Xia YH, Xuan S, Huising MO, Kieffer TJ, Lynn FC, Johnson JD. Chu CMJ, et al. Among authors: huising mo. Diabetes. 2022 Dec 1;71(12):2612-2631. doi: 10.2337/db21-1065. Diabetes. 2022. PMID: 36170671
86 results