Chen T - Search Results

1

Design, synthesis and biological evaluation of novel FAK inhibitors with better selectivity over IR than TAE226.

Chen T, Liu Y, Liu J, Tang M, Huang H, Bai C, Si W, Yang T, Yuan X, Wen Y, Chen L. Chen T, et al. Among authors: chen l. Bioorg Chem. 2022 Jul;124:105790. doi: 10.1016/j.bioorg.2022.105790. Epub 2022 Apr 6. Bioorg Chem. 2022. PMID: 35452915

2

Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase.

Chen T, Liu Y, Shi M, Tang M, Si W, Yuan X, Wen Y, Chen L. Chen T, et al. Among authors: chen l. Bioorg Med Chem Lett. 2021 Dec 15;54:128433. doi: 10.1016/j.bmcl.2021.128433. Epub 2021 Oct 30. Bioorg Med Chem Lett. 2021. PMID: 34757216

3

Molecular Docking, Molecular Dynamics Simulations, and Free Energy Calculation Insights into the Binding Mechanism between VS-4718 and Focal Adhesion Kinase.

Shi M, Chen T, Wei S, Zhao C, Zhang X, Li X, Tang X, Liu Y, Yang Z, Chen L. Shi M, et al. Among authors: chen l, chen t. ACS Omega. 2022 Aug 31;7(36):32442-32456. doi: 10.1021/acsomega.2c03951. eCollection 2022 Sep 13. ACS Omega. 2022. PMID: 36119979 Free PMC article.

4

A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.

Zhao W, Chen L, Li HM, Wang DJ, Li DS, Chen T, Yuan ZP, Tang YJ. Zhao W, et al. Among authors: chen l, chen t. Bioorg Med Chem. 2014 Jun 1;22(11):2998-3007. doi: 10.1016/j.bmc.2014.03.048. Epub 2014 Apr 13. Bioorg Med Chem. 2014. PMID: 24775914

5

Discovery of thiazolidin-4-one urea analogues as novel multikinase inhibitors that potently inhibit FLT3 and VEGFR2.

Qi B, Xu X, Yang Y, Zhou Y, Chen T, Gong G, Yue X, Xu X, Hu L, He H. Qi B, et al. Among authors: chen t. Bioorg Med Chem. 2019 May 15;27(10):2127-2139. doi: 10.1016/j.bmc.2019.03.049. Epub 2019 Mar 25. Bioorg Med Chem. 2019. PMID: 30940564

6

Discovery of 1,6-naphthyridinone-based MET kinase inhibitor bearing quinoline moiety as promising antitumor drug candidate.

Chen T, Zhuo LS, Liu PF, Fang WR, Li YM, Huang W. Chen T, et al. Eur J Med Chem. 2020 Apr 15;192:112174. doi: 10.1016/j.ejmech.2020.112174. Epub 2020 Feb 21. Eur J Med Chem. 2020. PMID: 32113049

7

Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4'-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways.

Xiao L, Zhao W, Li HM, Wan DJ, Li DS, Chen T, Tang YJ. Xiao L, et al. Among authors: chen t. Eur J Med Chem. 2014 Jun 10;80:267-77. doi: 10.1016/j.ejmech.2014.03.082. Epub 2014 Mar 30. Eur J Med Chem. 2014. PMID: 24793877

8

Discovery of N¹-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)-N³-(2-(2,6-difluorophenyl)-4-oxothiazolidin-3-yl)urea as a multi-tyrosine kinase inhibitor for drug-sensitive and drug-resistant cancers treatment.

Qi B, Yang Y, Gong G, He H, Yue X, Xu X, Hu Y, Li J, Chen T, Wan X, Zhang A, Zhou G. Qi B, et al. Among authors: chen t. Eur J Med Chem. 2019 Feb 1;163:10-27. doi: 10.1016/j.ejmech.2018.11.057. Epub 2018 Nov 23. Eur J Med Chem. 2019. PMID: 30503936

9

Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic podophyllum derivatives display antitumor activity.

Li JL, Zhao W, Zhou C, Zhang YX, Li HM, Tang YL, Liang XH, Chen T, Tang YJ. Li JL, et al. Among authors: chen t. Sci Rep. 2015 Oct 7;5:14814. doi: 10.1038/srep14814. Sci Rep. 2015. PMID: 26443888 Free PMC article.

10

Fluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells.

Zhao W, Yang Y, Zhang YX, Zhou C, Li HM, Tang YL, Liang XH, Chen T, Tang YJ. Zhao W, et al. Among authors: chen t. Sci Rep. 2015 Nov 26;5:17175. doi: 10.1038/srep17175. Sci Rep. 2015. PMID: 26608216 Free PMC article.

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