Pobbati AV - Search Results

1

The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras-MAPK Signaling in Epithelioid Hemangioendothelioma.

Ma S, Kanai R, Pobbati AV, Li S, Che K, Seavey CN, Hallett A, Burtscher A, Lamar JM, Rubin BP. Ma S, et al. Among authors: pobbati av. Clin Cancer Res. 2022 Jul 15;28(14):3116-3126. doi: 10.1158/1078-0432.CCR-22-0421. Clin Cancer Res. 2022. PMID: 35443056 Free PMC article. Clinical Trial.

2

Protein-Protein Interaction Disruptors of the YAP/TAZ-TEAD Transcriptional Complex.

Pobbati AV, Rubin BP. Pobbati AV, et al. Molecules. 2020 Dec 18;25(24):6001. doi: 10.3390/molecules25246001. Molecules. 2020. PMID: 33352993 Free PMC article. Review.

3

WWTR1(TAZ)-CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesis.

Seavey CN, Pobbati AV, Hallett A, Ma S, Reynolds JP, Kanai R, Lamar JM, Rubin BP. Seavey CN, et al. Among authors: pobbati av. Genes Dev. 2021 Apr 1;35(7-8):512-527. doi: 10.1101/gad.348220.120. Epub 2021 Mar 25. Genes Dev. 2021. PMID: 33766982 Free PMC article.

4

Design, Synthesis and Evaluation of a Series of 1,5-Diaryl-1,2,3-triazole-4-carbohydrazones as Inhibitors of the YAP-TAZ/TEAD Complex.

Gibault F, Sturbaut M, Coevoet M, Pugnière M, Burtscher A, Allemand F, Melnyk P, Hong W, Rubin BP, Pobbati AV, Guichou JF, Cotelle P, Bailly F. Gibault F, et al. Among authors: pobbati av. ChemMedChem. 2021 Sep 16;16(18):2823-2844. doi: 10.1002/cmdc.202100153. Epub 2021 Jul 1. ChemMedChem. 2021. PMID: 34032019

5

Inhibition of PI3K and MAPK pathways along with KIT inhibitors as a strategy to overcome drug resistance in gastrointestinal stromal tumors.

Gupta A, Ma S, Che K, Pobbati AV, Rubin BP. Gupta A, et al. Among authors: pobbati av. PLoS One. 2021 Jul 29;16(7):e0252689. doi: 10.1371/journal.pone.0252689. eCollection 2021. PLoS One. 2021. PMID: 34324512 Free PMC article.

6

Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex.

Che K, Pobbati AV, Seavey CN, Fedorov Y, Komar AA, Burtscher A, Ma S, Rubin BP. Che K, et al. Among authors: pobbati av. PLoS One. 2022 Apr 13;17(4):e0266143. doi: 10.1371/journal.pone.0266143. eCollection 2022. PLoS One. 2022. PMID: 35417479 Free PMC article.

7

Unraveling the Biology of Epithelioid Hemangioendothelioma, a TAZ-CAMTA1 Fusion Driven Sarcoma.

Seavey CN, Pobbati AV, Rubin BP. Seavey CN, et al. Among authors: pobbati av. Cancers (Basel). 2022 Jun 16;14(12):2980. doi: 10.3390/cancers14122980. Cancers (Basel). 2022. PMID: 35740643 Free PMC article. Review.

8

Loss of CDKN2A Cooperates with WWTR1(TAZ)-CAMTA1 Gene Fusion to Promote Tumor Progression in Epithelioid Hemangioendothelioma.

Seavey CN, Hallett A, Li S, Che K, Pobbati AV, Ma S, Burtscher A, Kanai R, Lamar JM, Rubin BP. Seavey CN, et al. Among authors: pobbati av. Clin Cancer Res. 2023 Jul 5;29(13):2480-2493. doi: 10.1158/1078-0432.CCR-22-2497. Clin Cancer Res. 2023. PMID: 36598859

9

Therapeutic targeting of TEAD transcription factors in cancer.

Pobbati AV, Kumar R, Rubin BP, Hong W. Pobbati AV, et al. Trends Biochem Sci. 2023 May;48(5):450-462. doi: 10.1016/j.tibs.2022.12.005. Epub 2023 Jan 26. Trends Biochem Sci. 2023. PMID: 36709077 Review.

10

Leveraging Hot Spots of TEAD-Coregulator Interactions in the Design of Direct Small Molecule Protein-Protein Interaction Disruptors Targeting Hippo Pathway Signaling.

Zhao B, Pobbati AV, Rubin BP, Stauffer S. Zhao B, et al. Among authors: pobbati av. Pharmaceuticals (Basel). 2023 Apr 13;16(4):583. doi: 10.3390/ph16040583. Pharmaceuticals (Basel). 2023. PMID: 37111340 Free PMC article. Review.

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