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Page 1
Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo.
Bertheloot D, Wanderley CW, Schneider AH, Schiffelers LD, Wuerth JD, Tödtmann JM, Maasewerd S, Hawwari I, Duthie F, Rohland C, Ribeiro LS, Jenster LM, Rosero N, Tesfamariam YM, Cunha FQ, Schmidt FI, Franklin BS. Bertheloot D, et al. Among authors: schmidt fi. EMBO Mol Med. 2022 Jun 8;14(6):e15415. doi: 10.15252/emmm.202115415. Epub 2022 Apr 19. EMBO Mol Med. 2022. PMID: 35438238 Free PMC article.
The intra- and extracellular functions of ASC specks.
Franklin BS, Latz E, Schmidt FI. Franklin BS, et al. Among authors: schmidt fi. Immunol Rev. 2018 Jan;281(1):74-87. doi: 10.1111/imr.12611. Immunol Rev. 2018. PMID: 29247990 Review.
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.
Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI. Koenig PA, et al. Among authors: schmidt fi. Science. 2021 Feb 12;371(6530):eabe6230. doi: 10.1126/science.abe6230. Epub 2021 Jan 12. Science. 2021. PMID: 33436526 Free PMC article.
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection.
Jenster LM, Lange KE, Normann S, vom Hemdt A, Wuerth JD, Schiffelers LDJ, Tesfamariam YM, Gohr FN, Klein L, Kaltheuner IH, Ebner S, Lapp DJ, Mayer J, Moecking J, Ploegh HL, Latz E, Meissner F, Geyer M, Kümmerer BM, Schmidt FI. Jenster LM, et al. Among authors: schmidt fi. J Exp Med. 2023 Jan 2;220(1):e20220837. doi: 10.1084/jem.20220837. Epub 2022 Oct 31. J Exp Med. 2023. PMID: 36315050 Free PMC article.
Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.
Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, Huang YS, Pichlmair A, Kümmerer BM, Sakoda Y, Schlee M, Brunotte L, Müller CE, Igarashi M, Kato H. Tsukamoto Y, et al. Among authors: schmidt fi. Science. 2023 Feb 10;379(6632):586-591. doi: 10.1126/science.add0875. Epub 2023 Feb 9. Science. 2023. PMID: 36758070
Mitochondrial damage activates the NLRP10 inflammasome.
Próchnicki T, Vasconcelos MB, Robinson KS, Mangan MSJ, De Graaf D, Shkarina K, Lovotti M, Standke L, Kaiser R, Stahl R, Duthie FG, Rothe M, Antonova K, Jenster LM, Lau ZH, Rösing S, Mirza N, Gottschild C, Wachten D, Günther C, Kufer TA, Schmidt FI, Zhong FL, Latz E. Próchnicki T, et al. Among authors: schmidt fi. Nat Immunol. 2023 Apr;24(4):595-603. doi: 10.1038/s41590-023-01451-y. Epub 2023 Mar 20. Nat Immunol. 2023. PMID: 36941400
Pyroptosis inhibiting nanobodies block Gasdermin D pore formation.
Kopp A, Hagelueken G, Jamitzky I, Moecking J, Schiffelers LDJ, Schmidt FI, Geyer M. Kopp A, et al. Among authors: schmidt fi. Nat Commun. 2023 Dec 1;14(1):7923. doi: 10.1038/s41467-023-43707-z. Nat Commun. 2023. PMID: 38040708 Free PMC article.
Brain endothelial GSDMD activation mediates inflammatory BBB breakdown.
Wei C, Jiang W, Wang R, Zhong H, He H, Gao X, Zhong S, Yu F, Guo Q, Zhang L, Schiffelers LDJ, Zhou B, Trepel M, Schmidt FI, Luo M, Shao F. Wei C, et al. Among authors: schmidt fi. Nature. 2024 May;629(8013):893-900. doi: 10.1038/s41586-024-07314-2. Epub 2024 Apr 17. Nature. 2024. PMID: 38632402
53 results