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The Effects of Weak and Strong CYP3A Induction by Rifampicin on the Pharmacokinetics of Five Progestins and Ethinylestradiol Compared to Midazolam.
Wiesinger H, Klein S, Rottmann A, Nowotny B, Riecke K, Gashaw I, Brudny-Klöppel M, Fricke R, Höchel J, Friedrich C. Wiesinger H, et al. Among authors: friedrich c. Clin Pharmacol Ther. 2020 Oct;108(4):798-807. doi: 10.1002/cpt.1848. Epub 2020 May 11. Clin Pharmacol Ther. 2020. PMID: 32275771 Free PMC article. Clinical Trial.
Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women.
Panknin O, Wagenfeld A, Bone W, Bender E, Nowak-Reppel K, Fernández-Montalván AE, Nubbemeyer R, Bäurle S, Ring S, Schmees N, Prien O, Schäfer M, Friedrich C, Zollner TM, Steinmeyer A, Mueller T, Langer G. Panknin O, et al. Among authors: friedrich c. J Med Chem. 2020 Oct 22;63(20):11854-11881. doi: 10.1021/acs.jmedchem.0c01076. Epub 2020 Oct 6. J Med Chem. 2020. PMID: 32960053
Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study.
Morice A, Smith JA, McGarvey L, Birring SS, Parker SM, Turner A, Hummel T, Gashaw I, Fels L, Klein S, Francke K, Friedrich C. Morice A, et al. Among authors: friedrich c. Eur Respir J. 2021 Nov 18;58(5):2004240. doi: 10.1183/13993003.04240-2020. Print 2021 Nov. Eur Respir J. 2021. PMID: 33986030 Free PMC article. Clinical Trial.
Preclinical and Clinical Pharmacokinetics and Bioavailability in Healthy Volunteers of a Novel Formulation of the Selective P2X3 Receptor Antagonist Eliapixant.
Francke K, Chattopadhyay N, Klein S, Rottmann A, Krickau D, van de Wetering J, Friedrich C. Francke K, et al. Among authors: friedrich c. Eur J Drug Metab Pharmacokinet. 2023 Jan;48(1):75-87. doi: 10.1007/s13318-022-00805-5. Epub 2022 Dec 5. Eur J Drug Metab Pharmacokinet. 2023. PMID: 36469250 Clinical Trial.
749 results