Zhang Z - Search Results

1

Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance.

Wang Z, Wang J, Wang Y, Xiang S, Song X, Tu Z, Zhou Y, Zhang ZM, Zhang Z, Ding K, Lu X. Wang Z, et al. Among authors: zhang z, zhang zm. J Med Chem. 2022 Apr 28;65(8):6325-6337. doi: 10.1021/acs.jmedchem.2c00308. Epub 2022 Apr 15. J Med Chem. 2022. PMID: 35426680

2

Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.

Zhang Z, Hou S, Chen H, Ran T, Jiang F, Bian Y, Zhang D, Zhi Y, Wang L, Zhang L, Li H, Zhang Y, Tang W, Lu T, Chen Y. Zhang Z, et al. Among authors: zhang l, zhang d, zhang y. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2931-2935. doi: 10.1016/j.bmcl.2016.04.034. Epub 2016 Apr 22. Bioorg Med Chem Lett. 2016. PMID: 27142751

3

Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance.

Wang L, Zhang Q, Zhu G, Zhang Z, Zhi Y, Zhang L, Mao T, Zhou X, Chen Y, Lu T, Tang W. Wang L, et al. Among authors: zhang l, zhang q, zhang z. Eur J Med Chem. 2017 Apr 21;130:86-106. doi: 10.1016/j.ejmech.2017.02.041. Epub 2017 Feb 21. Eur J Med Chem. 2017. PMID: 28242553

4

Cell- and Tissue-Based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin.

Zhu D, Guo H, Chang Y, Ni Y, Li L, Zhang ZM, Hao P, Xu Y, Ding K, Li Z. Zhu D, et al. Among authors: zhang zm. Angew Chem Int Ed Engl. 2018 Jul 20;57(30):9284-9289. doi: 10.1002/anie.201802003. Epub 2018 Jun 25. Angew Chem Int Ed Engl. 2018. PMID: 29768700

5

Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance.

Wang L, Zhang Y, Zhang Q, Zhu G, Zhang Z, Duan C, Lu T, Tang W. Wang L, et al. Among authors: zhang q, zhang z, zhang y. Eur J Med Chem. 2019 Feb 1;163:243-255. doi: 10.1016/j.ejmech.2018.11.033. Epub 2018 Nov 16. Eur J Med Chem. 2019. PMID: 30529543

6

Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer.

Liu W , Zhang Z , Zhang ZM , Hao P , Ding K , Li Z . Liu W , et al. Among authors: zhang z, zhang zm. Chem Commun (Camb). 2019 Jan 31;55(11):1596-1599. doi: 10.1039/c8cc08753a. Chem Commun (Camb). 2019. PMID: 30656306

7

Quinolone antibiotic derivatives as new selective Axl kinase inhibitors.

Tan L, Zhang Z, Gao D, Chan S, Luo J, Tu ZC, Zhang ZM, Ding K, Ren X, Lu X. Tan L, et al. Among authors: zhang z, zhang zm. Eur J Med Chem. 2019 Mar 15;166:318-327. doi: 10.1016/j.ejmech.2019.01.065. Epub 2019 Jan 30. Eur J Med Chem. 2019. PMID: 30731400

8

Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors.

Cui S, Wang Y, Wang Y, Tang X, Ren X, Zhang L, Xu Y, Zhang Z, Zhang ZM, Lu X, Ding K. Cui S, et al. Among authors: zhang l, zhang z, zhang zm. Eur J Med Chem. 2019 Oct 1;179:470-482. doi: 10.1016/j.ejmech.2019.06.064. Epub 2019 Jun 25. Eur J Med Chem. 2019. PMID: 31271959

9

Novel phenanthridin-6(5H)-one derivatives as potent and selective BET bromodomain inhibitors: Rational design, synthesis and biological evaluation.

Zhi Y, Wang S, Huang W, Zeng S, Liang M, Zhang C, Ma Z, Wang Z, Zhang Z, Shen Z. Zhi Y, et al. Among authors: zhang c, zhang z. Eur J Med Chem. 2019 Oct 1;179:502-514. doi: 10.1016/j.ejmech.2019.06.067. Epub 2019 Jun 28. Eur J Med Chem. 2019. PMID: 31276895

10

Affinity-Based Protein Profiling Reveals Cellular Targets of Photoreactive Anticancer Inhibitors.

Ma N, Zhang ZM, Lee JS, Cheng K, Lin L, Zhang DM, Hao P, Ding K, Ye WC, Li Z. Ma N, et al. Among authors: zhang dm, zhang zm. ACS Chem Biol. 2019 Dec 20;14(12):2546-2552. doi: 10.1021/acschembio.9b00784. Epub 2019 Nov 26. ACS Chem Biol. 2019. PMID: 31742988

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