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Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury.
Martens S, Jeong M, Tonnus W, Feldmann F, Hofmans S, Goossens V, Takahashi N, Bräsen JH, Lee EW, Van der Veken P, Joossens J, Augustyns K, Fulda S, Linkermann A, Song J, Vandenabeele P. Martens S, et al. Cell Death Dis. 2017 Jun 29;8(6):e2904. doi: 10.1038/cddis.2017.298. Cell Death Dis. 2017. PMID: 28661484 Free PMC article.
MLKL in cancer: more than a necroptosis regulator.
Martens S, Bridelance J, Roelandt R, Vandenabeele P, Takahashi N. Martens S, et al. Cell Death Differ. 2021 Jun;28(6):1757-1772. doi: 10.1038/s41418-021-00785-0. Epub 2021 May 5. Cell Death Differ. 2021. PMID: 33953348 Free PMC article. Review.
Tozasertib Analogues as Inhibitors of Necroptotic Cell Death.
Hofmans S, Devisscher L, Martens S, Van Rompaey D, Goossens K, Divert T, Nerinckx W, Takahashi N, De Winter H, Van Der Veken P, Goossens V, Vandenabeele P, Augustyns K. Hofmans S, et al. Among authors: martens s. J Med Chem. 2018 Mar 8;61(5):1895-1920. doi: 10.1021/acs.jmedchem.7b01449. Epub 2018 Feb 20. J Med Chem. 2018. PMID: 29437386
Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs.
Martens S, Hofmans S, Declercq W, Augustyns K, Vandenabeele P. Martens S, et al. Trends Pharmacol Sci. 2020 Mar;41(3):209-224. doi: 10.1016/j.tips.2020.01.002. Epub 2020 Feb 5. Trends Pharmacol Sci. 2020. PMID: 32035657 Review.
Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death.
Adjemian S, Oltean T, Martens S, Wiernicki B, Goossens V, Vanden Berghe T, Cappe B, Ladik M, Riquet FB, Heyndrickx L, Bridelance J, Vuylsteke M, Vandecasteele K, Vandenabeele P. Adjemian S, et al. Among authors: martens s. Cell Death Dis. 2020 Nov 23;11(11):1003. doi: 10.1038/s41419-020-03209-y. Cell Death Dis. 2020. PMID: 33230108 Free PMC article.
Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state.
Ghazavi F, Huysentruyt J, De Coninck J, Kourula S, Martens S, Hassannia B, Wartewig T, Divert T, Roelandt R, Popper B, Hiergeist A, Tougaard P, Vanden Berghe T, Joossens M, Berx G, Takahashi N, Wahida A, Vandenabeele P. Ghazavi F, et al. Among authors: martens s. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2024508119. doi: 10.1073/pnas.2024508119. Proc Natl Acad Sci U S A. 2022. PMID: 35105800 Free PMC article.
636 results