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An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor.
Bhushan B, Granata D, Kaas CS, Kasimova MA, Ren Q, Cramer CN, White MD, Hansen AMK, Fledelius C, Invernizzi G, Deibler K, Coleman OD, Zhao X, Qu X, Liu H, Zurmühl SS, Kodra JT, Kawamura A, Münzel M. Bhushan B, et al. Among authors: cramer cn. Chem Sci. 2022 Feb 24;13(11):3256-3262. doi: 10.1039/d1sc06844j. eCollection 2022 Mar 16. Chem Sci. 2022. PMID: 35414877 Free PMC article.
An efficient mRNA display protocol yields potent bicyclic peptide inhibitors for FGFR3c: outperforming linear and monocyclic formats in affinity and stability.
Villequey C, Zurmühl SS, Cramer CN, Bhusan B, Andersen B, Ren Q, Liu H, Qu X, Yang Y, Pan J, Chen Q, Münzel M. Villequey C, et al. Among authors: cramer cn. Chem Sci. 2024 Mar 18;15(16):6122-6129. doi: 10.1039/d3sc04763f. eCollection 2024 Apr 24. Chem Sci. 2024. PMID: 38665530 Free PMC article.
Exploring ECD on a Benchtop Q Exactive Orbitrap Mass Spectrometer.
Fort KL, Cramer CN, Voinov VG, Vasil'ev YV, Lopez NI, Beckman JS, Heck AJR. Fort KL, et al. Among authors: cramer cn. J Proteome Res. 2018 Feb 2;17(2):926-933. doi: 10.1021/acs.jproteome.7b00622. Epub 2017 Dec 28. J Proteome Res. 2018. PMID: 29249155 Free PMC article.