Kelley RF - Search Results

1

Generation of a Porcine Antibody Fab Fragment Using Protein Engineering to Facilitate the Evaluation of Ocular Sustained Delivery Technology.

Kelley RF, Tesar DB, Wang Y, Agard NJ, Holder PG, Chan J, Comps-Agrar L, Horvath J, Horvath JD, Crowell SR. Kelley RF, et al. Mol Pharm. 2022 May 2;19(5):1540-1547. doi: 10.1021/acs.molpharmaceut.2c00048. Epub 2022 Apr 8. Mol Pharm. 2022. PMID: 35393854

2

Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains.

Wang Y, Lee GF, Kelley RF, Spellman MW. Wang Y, et al. Among authors: kelley rf. Glycobiology. 1996 Dec;6(8):837-42. doi: 10.1093/glycob/6.8.837. Glycobiology. 1996. PMID: 9023546

3

Tyrosine plays a dominant functional role in the paratope of a synthetic antibody derived from a four amino acid code.

Fellouse FA, Barthelemy PA, Kelley RF, Sidhu SS. Fellouse FA, et al. Among authors: kelley rf. J Mol Biol. 2006 Mar 17;357(1):100-14. doi: 10.1016/j.jmb.2005.11.092. Epub 2005 Dec 19. J Mol Biol. 2006. PMID: 16413576

4

Engineering and structural characterization of a linear polyubiquitin-specific antibody.

Matsumoto ML, Dong KC, Yu C, Phu L, Gao X, Hannoush RN, Hymowitz SG, Kirkpatrick DS, Dixit VM, Kelley RF. Matsumoto ML, et al. Among authors: kelley rf. J Mol Biol. 2012 May 4;418(3-4):134-44. doi: 10.1016/j.jmb.2011.12.053. Epub 2011 Dec 29. J Mol Biol. 2012. PMID: 22227388 Free article.

5

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge.

Li B, Tesar D, Boswell CA, Cahaya HS, Wong A, Zhang J, Meng YG, Eigenbrot C, Pantua H, Diao J, Kapadia SB, Deng R, Kelley RF. Li B, et al. Among authors: kelley rf. MAbs. 2014;6(5):1255-64. doi: 10.4161/mabs.29809. Epub 2014 Oct 30. MAbs. 2014. PMID: 25517310 Free PMC article.

6

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics.

Bumbaca Yadav D, Sharma VK, Boswell CA, Hotzel I, Tesar D, Shang Y, Ying Y, Fischer SK, Grogan JL, Chiang EY, Urban K, Ulufatu S, Khawli LA, Prabhu S, Joseph S, Kelley RF. Bumbaca Yadav D, et al. Among authors: kelley rf. J Biol Chem. 2015 Dec 11;290(50):29732-41. doi: 10.1074/jbc.M115.692434. Epub 2015 Oct 21. J Biol Chem. 2015. PMID: 26491012 Free PMC article.

7

Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation.

Gong Q, Hazen M, Marshall B, Crowell SR, Ou Q, Wong AW, Phung W, Vernes JM, Meng YG, Tejada M, Andersen D, Kelley RF. Gong Q, et al. Among authors: kelley rf. MAbs. 2016 Aug-Sep;8(6):1098-106. doi: 10.1080/19420862.2016.1189049. Epub 2016 May 24. MAbs. 2016. PMID: 27216702 Free PMC article.

8

Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab.

Shatz W, Hass PE, Mathieu M, Kim HS, Leach K, Zhou M, Crawford Y, Shen A, Wang K, Chang DP, Maia M, Crowell SR, Dickmann L, Scheer JM, Kelley RF. Shatz W, et al. Among authors: kelley rf. Mol Pharm. 2016 Sep 6;13(9):2996-3003. doi: 10.1021/acs.molpharmaceut.6b00345. Epub 2016 Jun 14. Mol Pharm. 2016. PMID: 27244474

9

Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye.

Tesar D, Luoma J, Wyatt EA, Shi C, Shatz W, Hass PE, Mathieu M, Yi L, Corn JE, Maass KF, Wang K, Dion MZ, Andersen N, Loyet KM, van Lookeren Campagne M, Rajagopal K, Dickmann L, Scheer JM, Kelley RF. Tesar D, et al. Among authors: kelley rf. MAbs. 2017 Nov/Dec;9(8):1297-1305. doi: 10.1080/19420862.2017.1372078. Epub 2017 Aug 30. MAbs. 2017. PMID: 28854082 Free PMC article.

10

In Vivo Stability Profiles of Anti-factor D Molecules Support Long-Acting Delivery Approaches.

Loyet KM, Hass PE, Sandoval WN, Morando A, Liu P, Shatz W, Dickmann L, Kenrick M, Good J, Davancaze T, Morimoto AM, Kelley RF, Scheer JM. Loyet KM, et al. Among authors: kelley rf. Mol Pharm. 2019 Jan 7;16(1):86-95. doi: 10.1021/acs.molpharmaceut.8b00871. Epub 2018 Dec 3. Mol Pharm. 2019. PMID: 30444371

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