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Removal of BFL-1 sensitises some melanoma cells to killing by BH3 mimetic drugs.
Gangoda L, Schenk RL, Tai L, Szeto P, Cheung JG, Strasser A, Lessene G, Shackleton M, Herold MJ. Gangoda L, et al. Among authors: shackleton m. Cell Death Dis. 2022 Apr 4;13(4):301. doi: 10.1038/s41419-022-04776-y. Cell Death Dis. 2022. PMID: 35379799 Free PMC article. No abstract available.
CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity.
Boyle SE, Fedele CG, Corbin V, Wybacz E, Szeto P, Lewin J, Young RJ, Wong A, Fuller R, Spillane J, Speakman D, Donahoe S, Pohl M, Gyorki D, Henderson MA, Johnstone RW, Papenfuss AT, Shackleton M. Boyle SE, et al. Among authors: shackleton m. Cancer Res. 2016 Jul 1;76(13):3965-77. doi: 10.1158/0008-5472.CAN-15-2377. Epub 2016 Jun 20. Cancer Res. 2016. PMID: 27325642
Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP.
Paul PJ, Raghu D, Chan AL, Gulati T, Lambeth L, Takano E, Herold MJ, Hagekyriakou J, Vessella RL, Fedele C, Shackleton M, Williams ED, Fox S, Williams S, Haupt S, Gamell C, Haupt Y. Paul PJ, et al. Among authors: shackleton m. Oncogene. 2016 Dec 1;35(48):6235-6245. doi: 10.1038/onc.2016.159. Epub 2016 Sep 19. Oncogene. 2016. PMID: 27641331
Somatic Hypermutation of the YAP Oncogene in a Human Cutaneous Melanoma.
Zhang X, Tang JZ, Vergara IA, Zhang Y, Szeto P, Yang L, Mintoff C, Colebatch A, McIntosh L, Mitchell KA, Shaw E, Rizos H, Long GV, Hayward N, McArthur GA, Papenfuss AT, Harvey KF, Shackleton M. Zhang X, et al. Among authors: shackleton m. Mol Cancer Res. 2019 Jul;17(7):1435-1449. doi: 10.1158/1541-7786.MCR-18-0407. Epub 2019 Mar 4. Mol Cancer Res. 2019. PMID: 30833299 Free article.
Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling.
Vergara IA, Mintoff CP, Sandhu S, McIntosh L, Young RJ, Wong SQ, Colebatch A, Cameron DL, Kwon JL, Wolfe R, Peng A, Ellul J, Dou X, Fedele C, Boyle S, Arnau GM, Raleigh J, Hatzimihalis A, Szeto P, Mooi J, Widmer DS, Cheng PF, Amann V, Dummer R, Hayward N, Wilmott J, Scolyer RA, Cho RJ, Bowtell D, Thorne H, Alsop K, Cordner S, Woodford N, Leditschke J, O'Brien P, Dawson SJ, McArthur GA, Mann GJ, Levesque MP, Papenfuss AT, Shackleton M. Vergara IA, et al. Among authors: shackleton m. Nat Commun. 2021 Mar 4;12(1):1434. doi: 10.1038/s41467-021-21576-8. Nat Commun. 2021. PMID: 33664264 Free PMC article.
UHRF1/UBE2L6/UBR4-mediated ubiquitination regulates EZH2 abundance and thereby melanocytic differentiation phenotypes in melanoma.
Kuser-Abali G, Zhang Y, Szeto P, Zhao P, Masoumi-Moghaddam S, Fedele CG, Leece I, Huang C, Cheung JG, Ameratunga M, Noguchi F, Andrews MC, Wong NC, Schittenhelm RB, Shackleton M. Kuser-Abali G, et al. Among authors: shackleton m. Oncogene. 2023 Apr;42(17):1360-1373. doi: 10.1038/s41388-023-02631-8. Epub 2023 Mar 11. Oncogene. 2023. PMID: 36906655 Free PMC article.
The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma.
Ramsdale R, Jorissen RN, Li FZ, Al-Obaidi S, Ward T, Sheppard KE, Bukczynska PE, Young RJ, Boyle SE, Shackleton M, Bollag G, Long GV, Tulchinsky E, Rizos H, Pearson RB, McArthur GA, Dhillon AS, Ferrao PT. Ramsdale R, et al. Among authors: shackleton m. Sci Signal. 2015 Aug 18;8(390):ra82. doi: 10.1126/scisignal.aab1111. Sci Signal. 2015. PMID: 26286024
180 results