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Wolbachia depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment.
Quek S, Cook DAN, Wu Y, Marriott AE, Steven A, Johnston KL, Ford L, Archer J, Hemingway J, Ward SA, Wagstaff SC, Turner JD, Taylor MJ. Quek S, et al. Among authors: ward sa. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2120003119. doi: 10.1073/pnas.2120003119. Epub 2022 Apr 4. Proc Natl Acad Sci U S A. 2022. PMID: 35377795 Free PMC article.
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.
Biagini GA, Fisher N, Shone AE, Mubaraki MA, Srivastava A, Hill A, Antoine T, Warman AJ, Davies J, Pidathala C, Amewu RK, Leung SC, Sharma R, Gibbons P, Hong DW, Pacorel B, Lawrenson AS, Charoensutthivarakul S, Taylor L, Berger O, Mbekeani A, Stocks PA, Nixon GL, Chadwick J, Hemingway J, Delves MJ, Sinden RE, Zeeman AM, Kocken CH, Berry NG, O'Neill PM, Ward SA. Biagini GA, et al. Among authors: ward sa. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8298-303. doi: 10.1073/pnas.1205651109. Epub 2012 May 7. Proc Natl Acad Sci U S A. 2012. PMID: 22566611 Free PMC article.
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.
Ismail HM, Barton V, Phanchana M, Charoensutthivarakul S, Wong MH, Hemingway J, Biagini GA, O'Neill PM, Ward SA. Ismail HM, et al. Among authors: ward sa. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2080-5. doi: 10.1073/pnas.1600459113. Epub 2016 Feb 8. Proc Natl Acad Sci U S A. 2016. PMID: 26858419 Free PMC article.
Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.
Sharma R, Al Jayoussi G, Tyrer HE, Gamble J, Hayward L, Guimaraes AF, Davies J, Waterhouse D, Cook DA, Myhill LJ, Clare RH, Cassidy A, Steven A, Johnston KL, Ford L, Turner JD, Ward SA, Taylor MJ. Sharma R, et al. Among authors: ward sa. Sci Rep. 2016 Mar 21;6:23458. doi: 10.1038/srep23458. Sci Rep. 2016. PMID: 26996237 Free PMC article.
Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.
Aljayyoussi G, Tyrer HE, Ford L, Sjoberg H, Pionnier N, Waterhouse D, Davies J, Gamble J, Metuge H, Cook DAN, Steven A, Sharma R, Guimaraes AF, Clare RH, Cassidy A, Johnston KL, Myhill L, Hayward L, Wanji S, Turner JD, Taylor MJ, Ward SA. Aljayyoussi G, et al. Among authors: ward sa. Sci Rep. 2017 Mar 16;7(1):210. doi: 10.1038/s41598-017-00322-5. Sci Rep. 2017. PMID: 28303006 Free PMC article.
Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis.
Turner JD, Sharma R, Al Jayoussi G, Tyrer HE, Gamble J, Hayward L, Priestley RS, Murphy EA, Davies J, Waterhouse D, Cook DAN, Clare RH, Cassidy A, Steven A, Johnston KL, McCall J, Ford L, Hemingway J, Ward SA, Taylor MJ. Turner JD, et al. Among authors: ward sa. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9712-E9721. doi: 10.1073/pnas.1710845114. Epub 2017 Oct 23. Proc Natl Acad Sci U S A. 2017. PMID: 29078351 Free PMC article.
Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.
Sharma R, Aljayyoussi G, Tyrer HE, Gamble J, Hayward L, Guimaraes AF, Davies J, Waterhouse D, Cook DAN, Myhill LJ, Clare RH, Cassidy A, Steven A, Johnston KL, Ford L, Turner JD, Ward SA, Taylor MJ. Sharma R, et al. Among authors: ward sa. Sci Rep. 2018 Jan 8;8:46934. doi: 10.1038/srep46934. Sci Rep. 2018. PMID: 29308790 Free PMC article.
556 results