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New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents.
Chiarelli LR, Mori M, Beretta G, Gelain A, Pini E, Sammartino JC, Stelitano G, Barlocco D, Costantino L, Lapillo M, Poli G, Caligiuri I, Rizzolio F, Bellinzoni M, Tuccinardi T, Villa S, Meneghetti F. Chiarelli LR, et al. Among authors: sammartino jc. J Enzyme Inhib Med Chem. 2019 Dec;34(1):823-828. doi: 10.1080/14756366.2019.1589462. J Enzyme Inhib Med Chem. 2019. PMID: 30889995 Free PMC article.
New Insights into the Mechanism of Action of the Thienopyrimidine Antitubercular Prodrug TP053.
Chiarelli LR, Salina EG, Mori G, Azhikina T, Riabova O, Lepioshkin A, Grigorov A, Forbak M, Madacki J, Orena BS, Manfredi M, Gosetti F, Buzzi A, Degiacomi G, Sammartino JC, Marengo E, Korduláková J, Riccardi G, Mikušová K, Makarov V, Pasca MR. Chiarelli LR, et al. Among authors: sammartino jc. ACS Infect Dis. 2020 Feb 14;6(2):313-323. doi: 10.1021/acsinfecdis.9b00388. Epub 2019 Dec 2. ACS Infect Dis. 2020. PMID: 31729215
First triclosan-based macrocyclic inhibitors of InhA enzyme.
Rodriguez F, Saffon N, Sammartino JC, Degiacomi G, Pasca MR, Lherbet C. Rodriguez F, et al. Among authors: sammartino jc. Bioorg Chem. 2020 Jan;95:103498. doi: 10.1016/j.bioorg.2019.103498. Epub 2019 Dec 6. Bioorg Chem. 2020. PMID: 31855823
Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug.
Mori G, Orena BS, Chiarelli LR, Degiacomi G, Riabova O, Sammartino JC, Makarov V, Riccardi G, Pasca MR. Mori G, et al. Among authors: sammartino jc. Front Microbiol. 2020 Feb 25;11:292. doi: 10.3389/fmicb.2020.00292. eCollection 2020. Front Microbiol. 2020. PMID: 32158439 Free PMC article.
Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design.
Mori M, Stelitano G, Gelain A, Pini E, Chiarelli LR, Sammartino JC, Poli G, Tuccinardi T, Beretta G, Porta A, Bellinzoni M, Villa S, Meneghetti F. Mori M, et al. Among authors: sammartino jc. J Med Chem. 2020 Jul 9;63(13):7066-7080. doi: 10.1021/acs.jmedchem.0c00373. Epub 2020 Jun 25. J Med Chem. 2020. PMID: 32530281 Free PMC article.
58 results