Perera V - Search Results

1

Safety, pharmacokinetics, and pharmacodynamics of milvexian in healthy Japanese participants.

Perera V, Wang Z, Lubin S, Ueno T, Shiozaki T, Chen W, Xu X, Seiffert D, DeSouza M, Murthy B. Perera V, et al. Sci Rep. 2022 Mar 25;12(1):5165. doi: 10.1038/s41598-022-08768-y. Sci Rep. 2022. PMID: 35338177 Free PMC article. Clinical Trial.

2

First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects.

Perera V, Luettgen JM, Wang Z, Frost CE, Yones C, Russo C, Lee J, Zhao Y, LaCreta FP, Ma X, Knabb RM, Seiffert D, DeSouza M, Mugnier P, Cirincione B, Ueno T, Frost RJA. Perera V, et al. Br J Clin Pharmacol. 2018 May;84(5):876-887. doi: 10.1111/bcp.13520. Epub 2018 Mar 5. Br J Clin Pharmacol. 2018. PMID: 29346838 Free PMC article. Clinical Trial.

3

Phase I study of single-dose pharmacokinetics and pharmacodynamics of belatacept in adolescent kidney transplant recipients.

Moudgil A, Dharnidharka VR, Feig DI, Warshaw BL, Perera V, Murthy B, Roberts ME, Polinsky MS, Ettenger RB. Moudgil A, et al. Among authors: perera v. Am J Transplant. 2019 Apr;19(4):1218-1223. doi: 10.1111/ajt.15236. Epub 2019 Jan 22. Am J Transplant. 2019. PMID: 30582294 Free PMC article. Clinical Trial.

4

Antithrombotic Effects of Combined PAR (Protease-Activated Receptor)-4 Antagonism and Factor Xa Inhibition.

Meah MN, Raftis J, Wilson SJ, Perera V, Garonzik SM, Murthy B, Everlof JG, Aronson R, Luettgen J, Newby DE. Meah MN, et al. Among authors: perera v. Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):2678-2685. doi: 10.1161/ATVBAHA.120.314960. Epub 2020 Sep 10. Arterioscler Thromb Vasc Biol. 2020. PMID: 32907366 Free PMC article. Clinical Trial.

5

First-in-human study of milvexian, an oral, direct, small molecule factor XIa inhibitor.

Perera V, Wang Z, Luettgen J, Li D, DeSouza M, Cerra M, Seiffert D. Perera V, et al. Clin Transl Sci. 2022 Feb;15(2):330-342. doi: 10.1111/cts.13148. Epub 2021 Sep 24. Clin Transl Sci. 2022. PMID: 34558200 Free PMC article. Clinical Trial.

6

Single-Dose Pharmacokinetics of Milvexian in Participants with Mild or Moderate Hepatic Impairment Compared with Healthy Participants.

Perera V, Abelian G, Li D, Wang Z, Zhang L, Lubin S, Chen W, Bello A, Murthy B. Perera V, et al. Clin Pharmacokinet. 2022 Jun;61(6):857-867. doi: 10.1007/s40262-022-01110-9. Epub 2022 Mar 9. Clin Pharmacokinet. 2022. PMID: 35262846 Free PMC article. Clinical Trial.

7

Effects of Itraconazole and Diltiazem on the Pharmacokinetics and Pharmacodynamics of Milvexian, A Factor XIa Inhibitor.

Perera V, Wang Z, Lubin S, Christopher LJ, Chen W, Xu S, Seiffert D, DeSouza M, Murthy B. Perera V, et al. Cardiol Ther. 2022 Sep;11(3):407-419. doi: 10.1007/s40119-022-00266-6. Epub 2022 May 31. Cardiol Ther. 2022. PMID: 35641780 Free PMC article.

8

Single-Dose Pharmacokinetics of Milvexian in Participants with Normal Renal Function and Participants with Moderate or Severe Renal Impairment.

Perera V, Abelian G, Li D, Wang Z, Zhang L, Lubin S, Bello A, Murthy B. Perera V, et al. Clin Pharmacokinet. 2022 Oct;61(10):1405-1416. doi: 10.1007/s40262-022-01150-1. Epub 2022 Jul 30. Clin Pharmacokinet. 2022. PMID: 35906349 Free PMC article. Clinical Trial.

9

Effects of rifampin on the pharmacokinetics and pharmacodynamics of milvexian, a potent, selective, oral small molecule factor XIa inhibitor.

Perera V, Wang Z, Lubin S, Christopher LJ, Chen W, Xu S, Seiffert D, DeSouza M, Murthy B. Perera V, et al. Sci Rep. 2022 Dec 23;12(1):22239. doi: 10.1038/s41598-022-25936-2. Sci Rep. 2022. PMID: 36564395 Free PMC article. Clinical Trial.

10

Rationale and design of the AXIOMATIC-SSP phase II trial: Antithrombotic treatment with factor XIa inhibition to Optimize Management of Acute Thromboembolic events for Secondary Stroke Prevention.

Sharma M, Molina CA, Toyoda K, Bereczki D, Kasner SE, Lutsep HL, Tsivgoulis G, Ntaios G, Czlonkowska A, Shuaib A, Amarenco P, Endres M, Diener HC, Gailani D, Kahl A, Donovan M, Perera V, Li D, Hankey GJ. Sharma M, et al. Among authors: perera v. J Stroke Cerebrovasc Dis. 2022 Oct;31(10):106742. doi: 10.1016/j.jstrokecerebrovasdis.2022.106742. Epub 2022 Aug 27. J Stroke Cerebrovasc Dis. 2022. PMID: 36037679 Free PMC article. Clinical Trial.

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