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Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma.
Nijhuis A, Sikka A, Yogev O, Herendi L, Balcells C, Ma Y, Poon E, Eckold C, Valbuena GN, Xu Y, Liu Y, da Costa BM, Gruet M, Wickremesinghe C, Benito A, Kramer H, Montoya A, Carling D, Want EJ, Jamin Y, Chesler L, Keun HC. Nijhuis A, et al. Among authors: xu y. Nat Commun. 2022 Mar 16;13(1):1380. doi: 10.1038/s41467-022-28907-3. Nat Commun. 2022. PMID: 35296644 Free PMC article.
PTEN Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma.
Spear S, Le Saux O, Mirza HB, Iyer N, Tyson K, Grundland Freile F, Walton JB, Woodman C, Jarvis S, Ennis DP, Aguirre Hernandez C, Xu Y, Spiliopoulou P, Brenton JD, Costa-Pereira AP, Cook DP, Vanderhyden BC, Keun HC, Triantafyllou E, Arnold JN, McNeish IA. Spear S, et al. Among authors: xu y. Cancer Res. 2024 Nov 15;84(22):3772-3787. doi: 10.1158/0008-5472.CAN-23-3890. Cancer Res. 2024. PMID: 39186679 Free PMC article.
CD137 agonism enhances anti-PD1 induced activation of expanded CD8+ T cell clones in a neoadjuvant pancreatic cancer clinical trial.
Montagne JM, Mitchell JT, Tandurella JA, Christenson ES, Danilova LV, Deshpande A, Loth M, Sidiropoulos DN, Davis-Marcisak E, Bergman DR, Zhu Q, Wang H, Kagohara LT, Engle LL, Green BF, Favorov AV, Ho WJ, Lim SJ, Zhang R, Li P, Gai J, Mo G, Mitchell S, Wang R, Vaghasia A, Hou W, Xu Y, Zimmerman JW, Elisseeff JH, Yegnasubramanian S, Anders RA, Jaffee EM, Zheng L, Fertig EJ. Montagne JM, et al. Among authors: xu y. iScience. 2024 Dec 10;28(1):111569. doi: 10.1016/j.isci.2024.111569. eCollection 2025 Jan 17. iScience. 2024. PMID: 39811671 Free PMC article.
Splicing to orchestrate cell fate.
Zhang X, Guo Z, Li Y, Xu Y. Zhang X, et al. Among authors: xu y. Mol Ther Nucleic Acids. 2024 Dec 6;36(1):102416. doi: 10.1016/j.omtn.2024.102416. eCollection 2025 Mar 11. Mol Ther Nucleic Acids. 2024. PMID: 39811494 Free PMC article. Review.
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