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Native and activated antithrombin inhibits TMPRSS2 activity and SARS-CoV-2 infection.
Wettstein L, Immenschuh P, Weil T, Conzelmann C, Almeida-Hernández Y, Hoffmann M, Kempf A, Nehlmeier I, Lotke R, Petersen M, Stenger S, Kirchhoff F, Sauter D, Pöhlmann S, Sanchez-Garcia E, Münch J. Wettstein L, et al. Among authors: almeida hernandez y. J Med Virol. 2023 Jan;95(1):e28124. doi: 10.1002/jmv.28124. Epub 2022 Sep 16. J Med Virol. 2023. PMID: 36056630 Free PMC article.
Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection.
Harms M, Smith N, Han M, Groß R, von Maltitz P, Stürzel C, Ruiz-Blanco YB, Almeida-Hernández Y, Rodriguez-Alfonso A, Cathelin D, Caspar B, Tahar B, Sayettat S, Bekaddour N, Vanshylla K, Kleipass F, Wiese S, Ständker L, Klein F, Lagane B, Boonen A, Schols D, Benichou S, Sanchez-Garcia E, Herbeuval JP, Münch J. Harms M, et al. Among authors: almeida hernandez y. Sci Adv. 2023 Jul 7;9(27):eadf8251. doi: 10.1126/sciadv.adf8251. Epub 2023 Jul 5. Sci Adv. 2023. PMID: 37406129 Free PMC article.
Structure and stability of the Human respiratory syncytial virus M2-1 RNA-binding core domain reveals a compact and cooperative folding unit.
Molina IG, Josts I, Almeida Hernandez Y, Esperante S, Salgueiro M, Garcia Alai MM, de Prat-Gay G, Tidow H. Molina IG, et al. Among authors: almeida hernandez y. Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):23-30. doi: 10.1107/S2053230X17017381. Epub 2017 Dec 15. Acta Crystallogr F Struct Biol Commun. 2018. PMID: 29372904 Free PMC article.
Fatty acid conjugated EPI-X4 derivatives with increased activity and in vivo stability.
Harms M, Haase A, Rodríguez-Alfonso A, Löffler J, Almeida-Hernández Y, Ruiz-Blanco YB, Albers D, Gilg A, von Bank F, Zech F, Groß R, Datta M, Jaikishan J, Draphoen B, Habib M, Ständker L, Wiese S, Lindén M, Winter G, Rasche V, Beer AJ, Jumaa H, Abadi AH, Kirchhoff F, Busch M, Dünker N, Sanchez-Garcia E, Münch J. Harms M, et al. Among authors: almeida hernandez y. J Control Release. 2024 Sep;373:583-598. doi: 10.1016/j.jconrel.2024.07.049. Epub 2024 Jul 30. J Control Release. 2024. PMID: 39047872 Free article.
TopBP1 utilises a bipartite GINS binding mode to support genome replication.
Day M, Tetik B, Parlak M, Almeida-Hernández Y, Räschle M, Kaschani F, Siegert H, Marko A, Sanchez-Garcia E, Kaiser M, Barker IA, Pearl LH, Oliver AW, Boos D. Day M, et al. Among authors: almeida hernandez y. Nat Commun. 2024 Feb 27;15(1):1797. doi: 10.1038/s41467-024-45946-0. Nat Commun. 2024. PMID: 38413589 Free PMC article.
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