Arnold P - Search Results

1

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.

Prieto Huarcaya S, Drobny A, Marques ARA, Di Spiezio A, Dobert JP, Balta D, Werner C, Rizo T, Gallwitz L, Bub S, Stojkovska I, Belur NR, Fogh J, Mazzulli JR, Xiang W, Fulzele A, Dejung M, Sauer M, Winner B, Rose-John S, Arnold P, Saftig P, Zunke F. Prieto Huarcaya S, et al. Among authors: arnold p. Autophagy. 2022 May;18(5):1127-1151. doi: 10.1080/15548627.2022.2045534. Epub 2022 Apr 28. Autophagy. 2022. PMID: 35287553 Free PMC article.

2

Calcium negatively regulates meprin β activity and attenuates substrate cleavage.

Arnold P, Schmidt F, Prox J, Zunke F, Pietrzik C, Lucius R, Becker-Pauly C. Arnold P, et al. FASEB J. 2015 Aug;29(8):3549-57. doi: 10.1096/fj.15-272310. Epub 2015 May 8. FASEB J. 2015. PMID: 25957281

3

Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2.

Zunke F, Andresen L, Wesseler S, Groth J, Arnold P, Rothaug M, Mazzulli JR, Krainc D, Blanz J, Saftig P, Schwake M. Zunke F, et al. Among authors: arnold p. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3791-6. doi: 10.1073/pnas.1514005113. Epub 2016 Mar 21. Proc Natl Acad Sci U S A. 2016. PMID: 27001828 Free PMC article.

4

Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells.

Cabron AS, El Azzouzi K, Boss M, Arnold P, Schwarz J, Rosas M, Dobert JP, Pavlenko E, Schumacher N, Renné T, Taylor PR, Linder S, Rose-John S, Zunke F. Cabron AS, et al. Among authors: arnold p. J Immunol. 2018 Nov 15;201(10):3106-3118. doi: 10.4049/jimmunol.1701556. Epub 2018 Oct 24. J Immunol. 2018. PMID: 30355783 Free PMC article.

5

Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation.

Pavlenko E, Cabron AS, Arnold P, Dobert JP, Rose-John S, Zunke F. Pavlenko E, et al. Among authors: arnold p. Int J Mol Sci. 2019 May 4;20(9):2198. doi: 10.3390/ijms20092198. Int J Mol Sci. 2019. PMID: 31060243 Free PMC article. Review.

6

Toxic Metamorphosis-How Changes from Lysosomal to Cytosolic pH Modify the Alpha-Synuclein Aggregation Pattern.

Eymsh B, Drobny A, Heyn TR, Xiang W, Lucius R, Schwarz K, Keppler JK, Zunke F, Arnold P. Eymsh B, et al. Among authors: arnold p. Biomacromolecules. 2020 Dec 14;21(12):4673-4684. doi: 10.1021/acs.biomac.0c00629. Epub 2020 Oct 13. Biomacromolecules. 2020. PMID: 32986422

7

Alpha Synuclein Connects the Gut-Brain Axis in Parkinson's Disease Patients - A View on Clinical Aspects, Cellular Pathology and Analytical Methodology.

Schaeffer E, Kluge A, Böttner M, Zunke F, Cossais F, Berg D, Arnold P. Schaeffer E, et al. Among authors: arnold p. Front Cell Dev Biol. 2020 Sep 8;8:573696. doi: 10.3389/fcell.2020.573696. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 33015066 Free PMC article. Review.

8

Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain.

Dobert JP, Cabron AS, Arnold P, Pavlenko E, Rose-John S, Zunke F. Dobert JP, et al. Among authors: arnold p. Biomedicines. 2020 Oct 30;8(11):463. doi: 10.3390/biomedicines8110463. Biomedicines. 2020. PMID: 33143292 Free PMC article.

9

Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties.

Bunk J, Prieto Huarcaya S, Drobny A, Dobert JP, Walther L, Rose-John S, Arnold P, Zunke F. Bunk J, et al. Among authors: arnold p. Front Cell Dev Biol. 2021 Feb 11;9:581805. doi: 10.3389/fcell.2021.581805. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33681191 Free PMC article.

10

Cell Surface Processing of CD109 by Meprin β Leads to the Release of Soluble Fragments and Reduced Expression on Extracellular Vesicles.

Lückstädt W, Bub S, Koudelka T, Pavlenko E, Peters F, Somasundaram P, Becker-Pauly C, Lucius R, Zunke F, Arnold P. Lückstädt W, et al. Among authors: arnold p. Front Cell Dev Biol. 2021 Mar 2;9:622390. doi: 10.3389/fcell.2021.622390. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33738281 Free PMC article.

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