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HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression.
Li L, Kim JH, Lu W, Williams DM, Kim J, Cope L, Rampal RK, Koche RP, Xian L, Luo LZ, Vasiljevic M, Matson DR, Zhao ZJ, Rogers O, Stubbs MC, Reddy K, Romero AR, Psaila B, Spivak JL, Moliterno AR, Resar LMS. Li L, et al. Among authors: reddy k. Blood. 2022 May 5;139(18):2797-2815. doi: 10.1182/blood.2021013925. Blood. 2022. PMID: 35286385 Free PMC article.
The High Mobility Group A1 (HMGA1) gene is highly overexpressed in human uterine serous carcinomas and carcinosarcomas and drives Matrix Metalloproteinase-2 (MMP-2) in a subset of tumors.
Hillion J, Roy S, Heydarian M, Cope L, Xian L, Koo M, Luo LZ, Kellyn K, Ronnett BM, Huso T, Armstrong D, Reddy K, Huso DL, Resar LMS. Hillion J, et al. Among authors: reddy k. Gynecol Oncol. 2016 Jun;141(3):580-587. doi: 10.1016/j.ygyno.2016.03.020. Epub 2016 Apr 8. Gynecol Oncol. 2016. PMID: 27001612 Free PMC article.
HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation.
Chia L, Wang B, Kim JH, Luo LZ, Shuai S, Herrera I, Chen SY, Li L, Xian L, Huso T, Heydarian M, Reddy K, Sung WJ, Ishiyama S, Guo G, Jaffee E, Zheng L, Cope LM, Gabrielson K, Wood L, Resar L. Chia L, et al. Among authors: reddy k. J Clin Invest. 2023 Mar 15;133(6):e151601. doi: 10.1172/JCI151601. J Clin Invest. 2023. PMID: 36919699 Free PMC article.
3,895 results