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Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy.
Kaur N, Ruiz-Velasco A, Raja R, Howell G, Miller JM, Abouleisa RRE, Ou Q, Mace K, Hille SS, Frey N, Binder P, Smith CP, Fachim H, Soran H, Swanton E, Mohamed TMA, Müller OJ, Wang X, Chernoff J, Cartwright EJ, Liu W. Kaur N, et al. Among authors: liu w. iScience. 2022 Feb 23;25(3):103973. doi: 10.1016/j.isci.2022.103973. eCollection 2022 Mar 18. iScience. 2022. PMID: 35281739 Free PMC article.
Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 reduction and couples hypertrophic signals to ventricular arrhythmogenesis.
Zi M, Kimura TE, Liu W, Jin J, Higham J, Kharche S, Hao G, Shi Y, Shen W, Prehar S, Mironov A, Neyses L, Bierhuizen MF, Boyett MR, Zhang H, Lei M, Cartwright EJ, Wang X. Zi M, et al. Among authors: liu w. J Biol Chem. 2011 May 20;286(20):17821-30. doi: 10.1074/jbc.M111.228791. Epub 2011 Mar 28. J Biol Chem. 2011. PMID: 21454599 Free PMC article. No abstract available.
Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury.
Egom EE, Mohamed TM, Mamas MA, Shi Y, Liu W, Chirico D, Stringer SE, Ke Y, Shaheen M, Wang T, Chacko S, Wang X, Solaro RJ, Fath-Ordoubadi F, Cartwright EJ, Lei M. Egom EE, et al. Among authors: liu w. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1487-95. doi: 10.1152/ajpheart.01003.2010. Epub 2011 Jun 24. Am J Physiol Heart Circ Physiol. 2011. PMID: 21705677 Free PMC article.
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.
Liu W, Zi M, Naumann R, Ulm S, Jin J, Taglieri DM, Prehar S, Gui J, Tsui H, Xiao RP, Neyses L, Solaro RJ, Ke Y, Cartwright EJ, Lei M, Wang X. Liu W, et al. Circulation. 2011 Dec 13;124(24):2702-15. doi: 10.1161/CIRCULATIONAHA.111.048785. Epub 2011 Nov 14. Circulation. 2011. PMID: 22082674 Free PMC article.
A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin.
Liu W, Zi M, Tsui H, Chowdhury SK, Zeef L, Meng QJ, Travis M, Prehar S, Berry A, Hanley NA, Neyses L, Xiao RP, Oceandy D, Ke Y, Solaro RJ, Cartwright EJ, Lei M, Wang X. Liu W, et al. Circ Heart Fail. 2013 Jul;6(4):833-44. doi: 10.1161/CIRCHEARTFAILURE.112.000123. Epub 2013 Jun 10. Circ Heart Fail. 2013. PMID: 23753531 Free PMC article.
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