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Discovery of a novel 2-aminopyrazine-3-carboxamide as a potent and selective inhibitor of Activin Receptor-Like Kinase-2 (ALK2) for the treatment of fibrodysplasia ossificans progressiva.
Ullrich T, Arista L, Weiler S, Teixeira-Fouchard S, Broennimann V, Stiefl N, Head V, Kramer I, Guth S. Ullrich T, et al. Among authors: guth s. Bioorg Med Chem Lett. 2022 May 15;64:128667. doi: 10.1016/j.bmcl.2022.128667. Epub 2022 Mar 8. Bioorg Med Chem Lett. 2022. PMID: 35276359
Mode of action-based risk assessment of genotoxic carcinogens.
Hartwig A, Arand M, Epe B, Guth S, Jahnke G, Lampen A, Martus HJ, Monien B, Rietjens IMCM, Schmitz-Spanke S, Schriever-Schwemmer G, Steinberg P, Eisenbrand G. Hartwig A, et al. Among authors: guth s. Arch Toxicol. 2020 Jun;94(6):1787-1877. doi: 10.1007/s00204-020-02733-2. Epub 2020 Jun 15. Arch Toxicol. 2020. PMID: 32542409 Free PMC article. Review.
Correction to: Mode of action-based risk assessment of genotoxic carcinogens.
Hartwig A, Arand M, Epe B, Guth S, Jahnke G, Lampen A, Martus HJ, Monien B, Rietjens IMCM, Schmitz-Spanke S, Schriever-Schwemmer G, Steinberg P, Eisenbrand G. Hartwig A, et al. Among authors: guth s. Arch Toxicol. 2020 Sep;94(9):3347. doi: 10.1007/s00204-020-02862-8. Arch Toxicol. 2020. PMID: 32696078 Free PMC article.
Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses.
Guth S, Hüser S, Roth A, Degen G, Diel P, Edlund K, Eisenbrand G, Engel KH, Epe B, Grune T, Heinz V, Henle T, Humpf HU, Jäger H, Joost HG, Kulling SE, Lampen A, Mally A, Marchan R, Marko D, Mühle E, Nitsche MA, Röhrdanz E, Stadler R, van Thriel C, Vieths S, Vogel RF, Wascher E, Watzl C, Nöthlings U, Hengstler JG. Guth S, et al. Arch Toxicol. 2020 May;94(5):1375-1415. doi: 10.1007/s00204-020-02725-2. Epub 2020 May 8. Arch Toxicol. 2020. PMID: 32382957 Free PMC article. Review.
Contribution to the ongoing discussion on fluoride toxicity.
Guth S, Hüser S, Roth A, Degen G, Diel P, Edlund K, Eisenbrand G, Engel KH, Epe B, Grune T, Heinz V, Henle T, Humpf HU, Jäger H, Joost HG, Kulling SE, Lampen A, Mally A, Marchan R, Marko D, Mühle E, Nitsche MA, Röhrdanz E, Stadler R, van Thriel C, Vieths S, Vogel RF, Wascher E, Watzl C, Nöthlings U, Hengstler JG. Guth S, et al. Arch Toxicol. 2021 Jul;95(7):2571-2587. doi: 10.1007/s00204-021-03072-6. Epub 2021 Jun 6. Arch Toxicol. 2021. PMID: 34095968 Free PMC article. Review.
Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds-a hypothesis.
Eisenbrand G, Baum M, Cartus AT, Diel P, Engel KH, Engeli B, Epe B, Grune T, Guth S, Haller D, Heinz V, Hellwig M, Hengstler JG, Henle T, Humpf HU, Jäger H, Joost HG, Kulling S, Lachenmeier DW, Lampen A, Leist M, Mally A, Marko D, Nöthlings U, Röhrdanz E, Roth A, Spranger J, Stadler R, Vieths S, Wätjen W, Steinberg P. Eisenbrand G, et al. Among authors: guth s. Arch Toxicol. 2022 Jun;96(6):1905-1914. doi: 10.1007/s00204-022-03296-0. Epub 2022 May 4. Arch Toxicol. 2022. PMID: 35504979
Nitrate and nitrite in the diet: how to assess their benefit and risk for human health.
Habermeyer M, Roth A, Guth S, Diel P, Engel KH, Epe B, Fürst P, Heinz V, Humpf HU, Joost HG, Knorr D, de Kok T, Kulling S, Lampen A, Marko D, Rechkemmer G, Rietjens I, Stadler RH, Vieths S, Vogel R, Steinberg P, Eisenbrand G. Habermeyer M, et al. Among authors: guth s. Mol Nutr Food Res. 2015 Jan;59(1):106-28. doi: 10.1002/mnfr.201400286. Epub 2014 Oct 14. Mol Nutr Food Res. 2015. PMID: 25164923 Review.
Comparison of points of departure between subchronic and chronic toxicity studies on food additives, food contaminants and natural food constituents.
Guth S, Roth A, Engeli B, Lachenmeier DW, Cartus AT, Hüser S, Baum M, Diel P, Eisenbrand G, Hengstler JG, Humpf HU, Joost HG, Lampen A, Leist M, Marko D, Steinberg P, Mally A, Zarn JA. Guth S, et al. Food Chem Toxicol. 2020 Dec;146:111784. doi: 10.1016/j.fct.2020.111784. Epub 2020 Sep 28. Food Chem Toxicol. 2020. PMID: 32998026
249 results